基于肠道微生态探讨反复妊娠丢失从脾肾论治之机理

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关键词：反复妊娠丢失；滑胎；肠道菌群；脾肾亏虚；补肾健脾；理论探讨

中图分类号：R271.4 文献标志码：A 文章编号：1007-3213（2025）12-3184-06

DOI：10.13359/j.cnki.gzxbtcm.2025.12.039

Exploring the Mechanism of Treating Recurrent Pregnancy Loss from the Perspective of Spleen and Kidney Based on Gut Microbiota

ZENG Yuerui'，CHEN Si1，2 ， LUO Songping1，2.3

1.TheFirst SchoolofClinical Medicine，Guangzhou UniversityofChinese Medicine，Guangzhou510405Guangdong，China; 2.The First Afiliated Hospital of Guangzhou Universityof Chinese Medicine，Guangzhou 510405 Guangdong，China; 3.National Key Laboratory of Traditional Chinese Medicine Syndrome，Guangzhou51Oo06 Guangdong，China）

Abstract：Recurrent pregnancy loss （RPL），termed as habitual abortion in traditional Chinese medicine（TCM）， is a common outcome of adverse pregnancy.TCM theory posits that spleen-kidneydeficiencyand insecurity of the Chong-Ren meridian constitute the fundamental pathogenesis of RPL.Clinically，spleen-tonifying and kidneyreplenishing therapies have demonstrated reliable eficacy，though their underlying mechanisms remain unclear. Recent studies have revealed that spleen-kidney deficiency may induce intestinal dysbacteriosis，while kidneytonifying and spleen-fortifying herbal formulas exhibit regulatory efectson gut microbiota.Notably，alterations in gut microbiota and their metabolites are closely associated with RPL pathogenesis.This article elucidates the interrelationship among RPL，gut microbiota，and spleen-kidney systems.Based on the pivotal role of gut microbiota in the prevalenceofRPL development and the corelationof physiological and pathological features of the spleen-kidneysystems with the gut microbiota，this article proposes that the modulation of gut microbiota may represent one of the mechanisms that TCM treats RPL via spleen-kidney regulation.

Keywords：recurrent pregnancy loss；habitual abortion；gut microbiota；spleen-kidney deficiency；tonifying kidney and fortifying spleen；theoretical exploration

反复妊娠丢失（recurrent pregnancy loss，RPL）是育龄期女性常见的不良妊娠结局之一。（剩余12786字）