七味金草花外洗液制备工艺优化与质量标准建立
打开文本图片集
关键词：七味金草花外洗液；绿原酸；高效液相色谱；正交试验；地骨皮；桑白皮；薄层色谱中图分类号：R282.5 文献标志码：A 文章编号：1007-3213（2025）12-3151-07DOI：10.13359/j.cnki.gzxbtcm.2025.12.034
Optimization of Preparation Process and Establishment of Quality Standards forQiweiJincaohua External Lotion
ZHAO Kunting'，ZHANG Cheng'，LIN Ying²，ZHEN Qingyu²，ZHU Wei²，CHEN Dacan² （1.ArtemisininResearch Center，Guangzhou UniversityofChinese Medicine，Guangzhou510405Guangdong，China；2.The Second ScholofClinicalMedicine，Guangzhou UniversityofChinese Medicine，Guangzhou51O120Guangdong，China）
Abstract：Objective To screen the optimal preparation processfor Qiwei Jincaohua External Lotion with stable and feasible formulation，and establishquality research methods to lay the foundation for its development as a hospital preparation.Methods Using chlorogenic acid content as the evaluation index，single-factor test were conducted，follwed byorthogonal test tooptimize the waterextraction process of Qiwei Jincaohua ExteralLotion. Theconcentration process was determined by weighted comparison of chlorogenic acid content and dry extract rate inconcentrated medicinal solutions under diffrent temperatureand pressure conditions，and the feasibilityof this method was verified.According tothe 2O2O editionof the Chinese Pharmacopoeia（PartI），thin-layerchromatography （TLC）identification was performed for Lycii Cortex and Mori Cortex in Qiuei Jincaohua External Lotion，and a quality standard was established for the determination of chlorogenic acid content.Results The optimal conditions were determined as folows：three extractioncycles，6O minutes extraction time，addition of6 times the amount of water，and vacuum drying at 9OC.The established high-performance liquid chromatography（HPLC）method for determining chlorogenic acid content in Qiwei Jincaohua External Lotionwas stableand feasible.The TLC identification methods for Mori Cortex and Lycii Cortex were simpleand reliable.Conclusion The optimized preparation process for Qiwei Jincaohua External Lotionis stable，reliable，and scientificaly reasonable，making it suitable for industrial production.
Keywords：Qiwei Jincaohua External Lotion；chlorogenic acid；high-performance liquid chromatography （HPLC）；orthogonal test；Mori Cortex；Lycii Cortex；thin-layer chromatography
特应性皮炎（AD）是一种以皮肤屏障功能障碍和慢性炎症反应为特征的慢性炎症性皮肤病[1-3]，多发于居住在城市地区或高收入国家/地区的儿童。（剩余7536字）
