针灸治疗脑缺血再灌注后神经细胞凋亡的研究进展

中图分类号：R246.9 文献标志码：A 文章编号：1007-3213（2025）12-3093-06

DOI：10.13359/j. cnki. gzxbtcm.2025.12.027

Research Progress on Acupuncture and Moxibustion in Treating Neuronal Apoptosis After Cerebral Ischemia-Reperfusion

WANG Peng'，DONG Xu2 ，ZHANG Ying²，HUO Hong²，ZHU Xingyan'，GONG Ruiqi³，WANG Dongyan²

（1.HeilongjiangUniversityofChineseMedicine，Harbin15O40Heilongjiang，China；2.TheSecondHospitalAffiliatedto HeilongjiangUniversityofChineseMedicine，Harbin15Oo01Heilongjiang，China；3.TheFourthHospitalAffliatedto Heilongjiang University of Chinese Medicine，Harbin 15oo77 Heilongjiang，China）

Abstract：Cerebral ischemia-reperfusion injury（CIRI） represents acritical pathological proces in cerebrovascular diseases.The restoration of blood flow folowing ischemia triggers a series of complex neurophysiological and biochemical changes，among which neuronal apoptosis is a central mechanism leading to severe neurological impairment after stroke.The pathophysiological mechanisms of neuronal apoptosis in CIRI involve multiple levels. Acupuncture and moxibustion，as traditional Chinese therapeutic modalities，demonstrate unique mechanisms of action in intervening inneuronal apoptosis.Although certain research achievements have beenmade regarding the intervention of acupuncture and moxibustion in neuronal apoptosis following CIRI，the specific mechanisms of actionremain incompletely elucidated，and the depth andbreadth of clinical research require further enhancement.This article systematicaly summarizes recent relevant studies，analyzes the mechanisms and clinical research progress of acupuncture and moxibustion in intervening in neuronal apoptosis，and proposes perspectives forfuture research directions，aiming to provide a more solid theoretical foundation and efective clinical guidance for the treatment of cerebrovascular diseases such as stroke.

Keywords：acupuncture and moxibustion；cerebral ischemia-reperfusion；neuronal apoptosis；research progress;review

近年来，我国脑卒中发病率总体呈现不断上升的趋势，其特点是发病率高、死亡率高、残疾率高，其中，缺血性脑卒中比例迄今已增长至80% 1。（剩余10274字）