中药干预多囊卵巢综合征的研究进展

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中图分类号：R271.9 文献标志码：A 文章编号：1007-3213（2025）11-2899-10

DOI：10.13359/j.cnki. gzxbtcm.2025.11.040

Abstract：Polycystic ovary syndrome （PCOS）is clinicallycharacterized by insulin resistance，ovulatory dysfunction and hyperandrogenemia，often accompanied byobesity，type2 diabetes，anddyslipidemia.This article reviews therecent studies on the intervention of PCOS with herbal medicines，including traditional Chinese medicine （TCM）compound formulas and single active compounds.The results demonstrate that both TCM compound formulasand single active compounds are efective on improving PCOS symptoms，with the advantages of multitarget actions and personalized treatment.TCM compound formulas for PCOScan be categorized into kidneytonifying formulas （e.g.，Antai Fanglou Decoction，Gui Zhu Yikun Formula， Liuwei Dihuang Pills，Bushen Huayu Formula），phlegm-resolving formulas （e.g.，Cang Fu Daotan Decoction，Erchen Decoction），liversoothing formulas （e.g.，Xiaoyao San，Shaoyao Gancao Decoction），and blood-activating formulas （e.g.，Jiawei Shaoyao Gancao Decoction，Gexia Zhuyu Decoction，Huayu Xiaozheng Decoction）.These compound formulas separately exhibit actions of tonifying kidney essence，soothing liver and relieving depression，and activating blood circulation to resolvestasis，whichare aligned with the TCMetiologyand pathogenesis of PCOS.Single active compounds from herbal medicine primarily include flavonoids，alkaloids，terpenoids and polyphenols. Extractives from herbal medicines exert therapeutic fectsbyinhibiting ovarian inflammatory responses and relieveing hyperandrogenemia insulin resistance.Key signaling pathways for the interventionof PCOS with TCM include PI3K/AKT/mTOR，SIRT1/AMPK，TLR4/NF- κB ，IRS1/PI3K/GLUT4，RIP1/RIP3/MLKL，HMGB1/RAGE，and Hippo-YAP.The review of recent advances in TCM formulas and single active compounds for the treatment of PCOS along with their underlying mechanisms will provide valuable insights for clinical management and new drug development for PCOS.

Keywords：polycystic ovary syndrome（PCOS）；traditional Chinese medicine（TCM）formulas；single activecompounds； therapeutic mechanism；multi-target； signaling pathways

多囊卵巢综合征（polycysticovarysyndrome，PCOS）是一种育龄期女性常见的内分泌代谢疾病，其患病率约为 18%[1] ，且逐年呈上升趋势[2]。（剩余15276字）