泄浊祛痛方抗高尿酸血症及抗痛风性关节炎的作用及网络药理学机制

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关键词：泄浊祛痛方；痛风；降尿酸；抗炎；网络药理学；大鼠

中图分类号：R285.5 文献标志码：A 文章编号：1007-3213（2025）11-2807-10

DOI：10.13359/j.cnki. gzxbtcm.2025.11.026

Abstract：Objective To observe the therapeutic efects and mechanism of Xiezhuo Qutong Formulaon gout. Methods（1）Animal experiments：A hyperuricemia（HUA） model was established in SD rats using hypoxanthine combined with potassium oxonate，and an acute gouty arthritis （AGA） model was induced by monosodium urate. Theefficacy and safety of Xiezhuo Qutong Formula in reducing serum uric acid levels and exerting antiinflammatory efects were evaluated.（2）Network pharmacology：The main active components and potential targets of Xiezhuo Qutong Formula were collcted，along with gout-related disease targets.The intersection of these targets yielded potential therapeutic targets.A protein-protein interaction（PPI）network was constructed，followed by Gene Ontology（GO）functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis.Results Xiezhuo Qutong Formula effectively reduced serum uric acid levels in HUA model rats without observed hepatorenal toxicity.Italso decreased joint inflammation index，jointswelingdegree， andinflammatorycytokine levels in AGA model rats.Network pharmacologyanalysis identified156overlapping targets between the drug and disease，among which TP53，STAT3，PIK3CA，BCL2，PIK3CD，PIK3CB， JUN，HDAC1，ESR1，andRELA maybe key targets of Xiezhuo Qutong Formula in treating gout. Combined with GO and KEGG enrichment analyses，the main involved pathways include PI3K/AKT，JAK2/STAT3，and NF-kB signaling pathways.Conclusion Xiezhuo Qutong Formula exerts uric acid-lowering and anti-inflammatory effects in the treatment of gout，and its potential mechanism involves the PI3K/AKT，JAK2/STAT3，and NF- κ B signaling pathways.

Keywords： Xiezhuo Qutong Formula；gout；uric acid reduction；anti-inflammation；network pharmacology; rats

痛风是尿酸钠晶体沉积在关节及软组织引发的炎症性疾病，高尿酸血症（hyperuricemia，HUA）是痛风发生的病理基础[。（剩余13802字）