正交试验结合总固物得率权重评分法优化加味温胆方水提工艺研究

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关键词：加味温胆方；柚皮苷；新橙皮苷；正交试验；提取工艺

中图分类号：R282.5 文献标志码：A 文章编号：1007-3213（2025）11-2840-05

DOI：10.13359/j.cnki. gzxbtcm.2025.11.030

Abstract：Objective To optimize the water extraction process of modified Wendan Formula.Methods The comprehensive scores of the content of naringin and neohesperidin as well as the extraction yields of solids were usedas the evaluation indexes，the number of decoctions，the decoction time andthe solid-liquid ratio as three factors were take into consideration， orthogonal experiment was designed to optimize the water extraction process of modified Wendan Formula.Results Combining the orthogonal experiment with the principle of energy conservation and emisson reduction in actual production，this study suggests thattheoptimized process was under the conditions of 1：8 for the solid-liquid ratio，decoction were performed twice，the first time was 1.5 hours，and the second time was1 hour.The averagecomposite score of validationof three batchesof modified Wendan Formula was 99.00% . Conclusion Such optimized process was stable，feasible and realizable，and it can be applied in water extraction process of modified Wendan Formula.

Keywords：modified Wendan Formula；naringin；neohesperidin；orthogonal experiment；extraction process

温胆汤（由半夏、竹茹、枳实、陈皮、甘草、生姜组成）出自唐代孙思邈的《备急千金药方》，具有理气化痰、和胃利胆之功效，主治胆郁痰扰证。（剩余5082字）