基于铁死亡探讨Nrf2/SLC7A11/GPX4信号通路在缺血性脑卒中发病中的作用及中医药干预研究进展

关键词：缺血性脑卒中；铁死亡；Nrf2/SLC7A11/GPX4信号通路；中医药；针灸中图分类号：R255.2 文献标志码：A 文章编号：1007-3213（2025）07-1825-06DOI：10.13359/j.cnki.gzxbtcm.2025.07.039

Study on the Role of Nrf2/SLC7A11/GPX4 Signaling Pathway in the Pathogenesisof Ischemic Stroke and Research Progresson Traditional Chinese Medicine Intervention Based on Ferroptosis

WEI Dacheng'，DUN Linglu'，LU Changjun'，AN Hongwei'，WANG Man²，YEQichao'，LIANG Hanchi'（1.Liuzhou Traditional Chinese Medical Hospital，Liuzhou 545O02 Guangxi，China；2.Guigang Donghui Hospital，Guigang 537000 Guangxi，China）

Abstract：Ischemic strokeisa disease resulting from thecerebral ischemiaand hypoxia caused by the blockage of brain vessels inthe brain，and is characterized bythe focal neurological signs.Pathologically，neuronal necrosis in the infarcted areaand the neuronal degeneration or delayed death of neurons in the ischemic penumbra， contribute to the morphological basis of the disease.Ischemic stroke is regulated by multiple processs，including ferroptosis，apoptosis，and autophagy.Ferroptosis，a type of iron-dependent cell death，is closely associated with ischemic stroke.Nuclear factor erythroid 2- related factor 2（Nrf2），a key transcription factor，plays a critical role in maintaining cellular redox balance and regulating inflammatory responses.Nrf2 promotes the expression of solute carrier family 7 member 11（SLC7A11）and glutathione peroxidase 4（GPX4），thereby activating the Nrf2 signaling pathway to counteract ferrptosis and protect cels from damage.This article reviews and analyzes recent experimental studies on traditional Chinese medicine（（TCM）therapy targetingthe Nrf/SLC7A11/GPX4 pathway to suppress ferroptosis.The studies have found that TCM therapy with herbal compounds，Chinese patent medicines， single herbal components and their active ingredients，and acupuncture and moxibustion can inhibit ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway，which will provide novel strategies for the TCM

interventionofischemicstroke

Keywords：ischemic stroke；ferroptosis；Nrf2/SLC7A11/GPX4 signaling pathway；traditional Chinese medicine; acupuncture and moxibustion

缺血性脑卒中为脑卒中的一种类型，是指由于脑供血动脉狭窄或闭塞导致脑供血不足，脑组织因持续性缺血出现神经元不可逆的损伤，最终导致神经功能障碍，严重影响患者的生活质量。（剩余10205字）