LRPPRC在非小细胞肺癌中的研究进展

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【中图分类号】R734.2 【文献标识码】A

Research progress of LRPPRC in non-small cell lung cancer

LE Sihong，ZHANG Qin，FANG Weidan， KUANG Peng， ZHANG Ling

DepartmentofOncology，TheFirstAfiliatedHospitalofNanchang University，Nanchang33oo6，China

Corresponding author： ZHANG Ling，Email： zhang_1202@163.com

【Abstract】Lung cancer is one of the deadliest malignant tumor globally， with non-small cell lung cancer （NSCLC） accounting for approximately 85% of cases. Given the heterogeneous nature of NSCLC and the unclear mechanisms underlying compensatory survival， there is an urgent need to explore novel molecular regulatory nodes to overcome treatment bottlenecks.The leucinerich pentatricopeptide repeat-containing protein （LRPPRC），a crucial RNA-binding protein， plays pivotal roles in NSCLC development， drug resistance， recurrence，and immunotherapy responses. This review was focusing on LRPPRC's regulatory mechanisms and therapeutic strategies in NSCLC， aiming to provide theoretical foundations and reference bases for clinical diagnosis and treatment of NSCLC.

【Keywords】Non-small cell lung cancer; LRPPRC; Drug resistance; Regulation mechanisms; Immunotherapy

肺癌是全球范围内致死率最高的恶性肿瘤，其年度新发病例和死亡人数持续上升，非小细胞肺癌（non-small cell lungcancer，NSCLC）约占肺癌病例总数的 85%[1] 。（剩余18251字）