辅助生殖技术对胎儿发育的影响

【中图分类号】R715 【文献标识码】A

Impactofassisted reproductive technologyonfetal development

LIU Yulu1#， WANG Ziqing1#， SUI Xuesong1， GAO Lu1.2.3

1.School ofBasicMedicineSciences，NavalMedical University，Shanghai 20o433，China

2.Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics，Shanghai 200001，

China

3.Shanghai KeyLaboratoryofDiseases ofEmbryoOriginal Disease，Shanghai2ooo3o，China

*Co-first authors： LIU Yulu and WANG Ziqing

Correspondingauthor： GAO Lu， Email： roadgao@163.com

【Abstract】Assisted reproductive technology （ART） offers infertile patients and couples carrying hereditary diseases the possibility of achieving normal conception and delivering healthy ofspring. However， ART is also associated with certain risks of complications. This paper primarily elucidates the potential factors and mechanisms through which ART may induce epigenetic alterations，particularly abnormalities in DNA methylation. It further explores the adverse effects of DNA methylation abnormalities at different genomic loci on fetal development， including an increased incidence of placental abnormalities，a higher risk of preeclampsia，and elevated rates of adverse perinatal outcomes.In addition，several improvement strategies are proposed，such as supplementation with moderate doses of folic acid and the implementation of single-embryo transfer，aiming to reduce ART-related epigenetic abnormalities and the risk of unfavorable pregnancy outcomes.

【Keywords】 Assisted reproductive technology; Infertility; DNA methylation; Pregnancy outcomes

数据显示，我国育龄夫妇不孕不育率已攀升至 12%～18% 。（剩余18188字）