犬尿氨酸代谢途径在眼科疾病的相关研究进展

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【中图分类号】R77 【文献标识码】A

Research progress of kynurenine pathway in ophthalmic diseases

LI Linwei1#， HUANG Pingping1#，XIE Hao²， ZHENG Mengxue1， XIAO Xuan12，YANGAnhuai1

1. DepartmentofOphthalmology， Renmin Hospital ofWuhan University， Wuhan 43o060，China

2.DepartmentofClinicalLaboratory，InstituteofTranslationalMedicine，RenminHospitalofWuhan

University， Wuhan 430060， China

*Co-first authors： LI Linwei and HUANG Pingping

Corresponding authors： YANG Anhuai， Email： yaho525@126.com; XIAO Xuan， Email： xiaoxuan1111@

whu.edu.cn

【Abstract】 The kynurenine pathway （KP） is the primary route of tryptophan metabolism in most mammalian cells，with approximately 95% of dietary tryptophan being converted into kynurenine and its downstream metabolites.Kynurenine is a central metabolite of tryptophan and possesses anti-inflammatory， antioxidant， and neuroprotective properties. Current research has shown that the KP plays a role in various diseases such as keratitis，cataract， glaucoma， and diabetic retinopathy. It was deeply involved in ocular pathophysiology through multiple mechanisms，including immunomodulation，antioxidant activity， neuroprotection，and mediation of photodamage.This paper presents a review of the role of KP in the eye and their related mechanisms in ocular diseases，including keratitis，cataract， glaucoma，and diabetic retinopathy，along with an outlook on future research.

【Keywords】Kynurenine metabolism; Keratitis; Cataract; Glaucoma; Diabetic retinopathy

犬尿氨酸代谢途径（kynureninepathway，KP）是色氨酸代谢的主要途径之一，其代谢产物在多种生理和病理过程中发挥重要作用，在众多领域中逐渐成为热点[。（剩余17823字）