肝纤维化中T淋巴细胞对肝星状细胞活化的影响

打开文本图片集

Effect of T lymphocyte on hepatic stellate cell activation in liver fibrosis

GONG Xiaoqian1， WEI Yehuang1， WANG Rongrong1， LIU Xudong2

1.GraduateSchool ofGuangxi UniversityofChineseMedicine，Nanning53ooo1，China

2. Department ofLiver Disease，Ruikang Hospital Affliated to Guangxi Universityof Chinese Medicine，

Nanning530011，China

Correspondingauthor： LIU Xudong， Email： lxdlhx@163.com

【Abstract】Liver fibrosis is a repair reaction of the whole body after liver injury caused by many causes （such as viral hepatitis and metabolic dysfunction-associated steatotic liver disease）. It is mainly manifested as excessive proliferation and deposition of extracellular matrix in liver tissue，which leads to abnormal changes in liver tissue structure，cirrhosis and liver failure，and affects the normal physiological function of liver.Activated hepatic stellate cels （HSC） are generally considered to be the main celltype that forms liver fibrosis.During liver fibrosis，immune cells play an important role in regulating the activation of HSC，such as interleukin17 （IL-17）， IL-10 and transforming growth factor β ，which are secreted by immune cells in the liver，including helper Tcells 17，Th1/Th2 cells，and regulatory Tcells. This paper mainly introduces the regulation of T lymphocytes on HSC activation and its impact in fibrosis to expand potential therapeutic approaches to modulate liver fibrosis.

【Keywords】T lymphocyte； Liver fibrosis； Hepatic stellate cels； Immune microenvironment

目前，慢性肝病的发生率和死亡率正在不断增长，主要与脂肪肝病和病毒性肝炎等代谢功能障碍相关疾病的增加有关[]。（剩余16151字）