饮食因素对肠易激综合征的影响：两样本孟德尔随机化研究
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Analysis of the effect of dietary factors on irritable bowel syndrome by Mendelianrandomizedmethod
1.2.3， Yanping1，2.3， WANG Huimin1.2.3， MA Xiaotong12.3， GUO Qinghong2，3，
CHEN Zhaofeng2.3
1. TheFirstClinicalMedicalSchool，Lanzhou University，Lanzhou73oooo，China
2.DepartmentofastroenterologyTheFirstHospitalofanzhouUniversity，Lanzhou73ooo，China
3.Gansu Clinical Medical Research CenterforDigestiveDiseases，Lanzhou 73oooo，China
Correspondingauthor：CHENZhaofeng，Email： zhfchen@lzu.edu.cn
【Abstract】 Objective To explore the causal relationship between dietary factors and the risk of developing irritable bowel syndrome （IBS） through Mendelian randomization analysis. Methods In the study， dietary factor-related characteristics from published Genome-Wide Association Study （GWAS） were selected and extracted as instrumental variables， and GWAS data on IBS were obtained from FinnGen Database.A two-sample Mendelian randomization analysis was primarily performed using the inverse variance weighted （IVW） method， and the test of heterogeneity，the testof pleiotropy，and sensitivityanalyses were performed to guarantee the stability and reliability of the results.Results The results of IVW method showed that an increase in the average weekly beer and cider intake might significantly increase the risk of developing IBS 95%CI （1.126， 3.708）， P=0.0 19].Conversely，an increase in coffee consumption[O 1=0.671 ， 95%CI （0.473， 0.952）， P=0.025 一 and dried fruits intake [OR =0.452 ， 95%CI （0.293， 0.697）， P<0.001 lappeared to correlatewith adecreased risk of developing IBS，where the results for dried fruit intake showed a similar patern of results in the weighted median method analysis [ OR=0.427 ，95%CI（0.231， 0.787）， P=0.006 ]. Conclusion The findings suggest a causal relationship between the average weekly intake of beer and cider，coffee，dried fruit and the risk of developing IBs. These findings emphasize the importance of making sound dietary choices in the prevention of IBS.
【Keywords】Dietary factors； Irritable bowel syndrome； Mendelian randomization； Genome-wide association study
肠易激综合征（irritablebowelsyndrome，IBS）是一种常见的功能性胃肠疾病，主要表现为腹痛或腹部不适，以及粪便形态或排便习惯的变化[]。（剩余15939字）