儿童大环内酯类耐药的重症肺炎支原体肺炎早期识别与治疗

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Early identification and treatment of macrolide-resistant severe Mycoplasmal pneumoniaepneumoniainchildren

YU Man122， YE Leping1

1.DepartmentofPediatricRespiratoryMedicine，Children'sMedical Center，Peking UniversityFirst

Hospital，Beijing102627，China

2.Department of Pediatrics，BeijingPinggu Hospital，Beijing1012oo，China

Corresponding author： YE Leping， Email： yeleping@bjmu.edu.cn

【Abstract】Mycoplasmal pneumoniae pneumonia （MPP） is a common respiratory disease in children.The incidence of severe MPP （SMPP） has increased and the situation is critical due to a variety offactors such as declining herd immunity，macrolide antibiotic resistance，delayed diagnosis and treatment，and mixed infection.Most children with SMPP have severe clinical symptoms and a long course of disease. SMPP is prone to serious complications such as lung consolidation， atelectasis，plastic bronchitis， necrotizing pneumonia，and extrapulmonary manifestations， leaving behind chronic lung diseases such as bronchiectasis and bronchiolitis obliterans， which affect the quality of children’s life. Children who are likely to develop SMPP should be given high attention. Early identification of SMPP with macrolide-resistant can be achieved by clinical manifestations， relevant laboratory tests，lung imaging，and bronchoscopic changes，and individualized treatment plan can be adjusted in time. Early diagnosis and effective treatment can alleviate the pain of children，shorten the courseofdisease，and reduce the incidenceof severe diseases.This article reviews the early identificationand treatment of severemacrolide-resistantMPPinchildren.

【Keywords】Mycoplasma pneumoniae； Macrolide antibiotics； Drug resistance； Severe pneumonia； Early identification； Treatment

肺炎支原体肺炎（Mycoplasmalpneumoniaepneumonia，MPP）由肺炎支原体（Mycoplasmapneumoniae，MP）感染引起，为儿童社区获得性肺炎的常见疾病，好发于学龄期以上的儿童，但近年来，在3月龄以上的婴幼儿中发病亦不少见[]。（剩余19358字）