血清CysC、CD147水平对颅内动脉狭窄支架成形术后再狭窄的预测价值

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中图分类号：R743 文献标志码：A DOI：10.11958/20250634

Abstract：ObjectiveTo explore the application value of serum cystatin C（CysC）and clusterof differentiation 147 （CD147） in predicting restenosis after intracranial artery stenosis stenting （ICASS）in patients withacute ischemic stroke （AIS）.MethodsA total of 151 AIS patients who received ICASS were selected as the study group，and112 healthy individuals who underwent physical examinations during the same period werechosen as thecontrol group.The study group was further divided into therestenosis group （30cases）andthe non-stenosis group（121cases）basedontherestenosis status within 6monthsafterICASS.The serum CysC levels of the subjects were detectedby immunoturbidimetry，andthe serum CD147 levelswere measured byenzyme-linked immunosorbent assay.Multivariate Logisticregresion analysis was conducted to identifyfactors influencing restenosis after ICASS inAIS patients.Thereceiver operating characteristic （ROC） curve was used to evaluate the aplication eficacyof serum CysCand CD147 levels in predicting restenosis after ICASS in AIS patients.ResultsSerumlevels ofCysCand CD147were higherinthe study groupthan those in thecontrol group（ P< 0.01）.The proportion of patients with stenosis degree >75% and serum levelsofCysC and CD147 were higher in the restenosis group than those in the non-stenosis group （ P<0.01 ）.The degree of stenosis >75% and the increased serum levels of CysC and CD147were risk factors for restenosisafter ICASS inAIS patients （ P<0.01 ）.ROC curve analysis showed thatserum CysCandCD147levels independently predictedtheAUCofAIS patients withrestenosisafterICASSwere0.845 and0.850，respectively，andthecombined predictedAUC wasO.942.Thecombined predictioneficiencywassignificantly better than that of single indicator prediction （P<0.05 ）.Conclusion The increased levels of serum CysC and CD147 in AIS patientsarerisk factorsforrestenosisafter ICASS，andthecombinationofthetwoismoreefective inpredicting intracranialarteryrestenosisafterICASSin AIS patients. Keywords：ischemic stroke; stents;cystatin C; acute ischemic stroke;CD147

急性缺血性脑卒中（AIS）是因局部脑组织血液供应不足引发的神经功能障碍性脑血管疾病。（剩余7973字）