乳腺癌治疗相关心脏毒性风险预测模型的研究进展

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【关键词】心血管疾病；心脏毒性；乳腺肿瘤；风险模型；预测模型；综述 【中图分类号】R541R595.4【文献标识码】A DOI：10.12114/j.issn.1007-9572.2024.0374

【Abstract】Cardiotoxicity is a common complication during the cancer treatment of breast cancer patients，increasing their physicaland mental sufferingandeven endangeringtheirlives.Therefore，earlyidentificationofhigh-riskpatients and taking targeted preventivemeasures iscrucial.Risk predictionmodels forcardiotoxicityrelated to breastcancer treatment are important methods forassessing high-risk patientsandhave been extensivelystudiedbyscholars bothdomesticalland internationally.The papercategorizes existing models into specificand general models basedonthe treatment methodsreceived bythestudypopulation.Itprovidesadetailedexplanationandcomparativeanalysisoftheconstructionprocesses，methods， predictivefactors，validationoffectiveness，andapplicationsofthesemodels.Theanalysisshowsthat theconstructionmethods of existing models mainlyusetraditional statistical methodssuchasLogisticregresionandCoxproportionalregresion，with afewusing machine learningalgorithms.The predictive factors are mostlyage，hypertension，diabetes，andBMI，with good predictive performance.However，there are significant diferences inthe predictivefactorsamong the models，andthere isan imbalancebetweendevelopmentandapplication.Futureresearchshouldfocusonclinicalapplicationandlocalizationverification of models，combineartificialinteligencetechnology，enrich new modeling methods，andconductmulti-center，large-sample prospective studies toimprovemodel stability.Thiswillprovideefectivescreening tolsforclinical healthcare professonals toidentifycardiotoxicity.Thispapercanserveasareferencefortheconstructionandapplicationof iskpredictionmodels for cardiotoxicity related to breast cancer treatment by clinical healthcare professionals in China.

【Key words】Cardiovascular diseases；Cardiotoxicity；Breast neoplasms；Hazard models； Prediction model;Review

世界卫生组织最新数据显示，乳腺癌在女性群体中发病率及死亡率均位居首位[]，其主要治疗方法包括手术、放疗、化疗和靶向治疗等「，但部分治疗可诱发心脏毒性［3-4]。（剩余18624字）