AMPK信号传导在帕金森病中的研究进展

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本文引用：阿与教比，力，乐，白7.DO 10.3969/j 19X2

中图分类号：R741.02 文献标志码：A 文章编号：1674-490X（2025）03-0001-07

Developments on AMPK signaling in Parkinson's disease

ADILAI Aibibuli'， JIANG Le¹，BAI Jing²

（1.School of Medicine， Xinjiang Institute of Science and Technology，Korla 841000，China; 2.School of Basic Medical Sciences，North China University of Science and Technology，Tangshan O63210， China）

Abstract ： Parkinson's disease （PD） is the second most common progressive neurodegenerative disease in the world. The most significant pathological changes in PD are the abnormal aggregation of α -synuclein and the progressve loss of dopaminergic neurons in the substantia nigra. Adenosine monophosphate-activated protein kinase（AMPK）is an energy and metabolism-regulating enzyme，and AMPK activation produces various effects related to PD. This article mainly expounds the basic regulation of AMPK and its impact on PD，providing a theoretical basis for AMPK-targeted therapy for PD.

Key words：adenosine monophosphate-activated protein kinase；Parkinson's disease；mitochondria；energy metabolism； α -synuclein

帕金森病是与衰老相关的影响人类健康的全球性神经变性疾病，有关数据显示，全世界有超过700万例帕金森病患者，而这一数字每年都在增加，估计到2040年帕金森病患者将达到1 200 万以上[1]。（剩余12795字）