细菌溶解产物联合布地格福对急性加重期 慢性阻塞性肺疾病患者血清炎症因子水平 及肺功能的影响

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Effect of bacterial lysate combined with budesonide on serum inflammatory cytokine levels and lung function in patients with acute exacerbation ofCOPD Wang Shuzhen，Gu Yunfeng，Yu Xiaobin.*Department of Respiratoryand CriticalCareMedicine，theThirdPeople'sHospitalofLuohe，Henan4623oo，China

【Abstract】ObjectiveToinvestigate theclinical efcacy of thecombination therapy of bacterial lysate and budesonide in patients with acute exacerbation of chronic obstructive pulmonarydisease （AECOPD）.Methods

Atotalof90 patientswith AECOPDadmited toour hospital from July2021 toJuly2024 wererandomly divided into two groups，with 45 patients in each group.Thecontrol group was treated with budesonide，while the studygroup wasalso treatedwith bacterial lysate.Theclinical eficacy，serum inflammatory factors，blood gas levels，immunoglobulin levels，lung function indicators，andadverse reactionsbetween the two groups of patients were compared.ResultsCompared with the control group，the total effective rate of thestudy group after treatment was higher （ P <0.05）.Compared with the control group，the study group had lower levels of tumor necrosis factor （TNF）- α ，interleukin（IL）-6，andC-reactiveprotein（CRP）aftertreatment（ P <0.05）.Compared with thecontrol group，the study group had higher blood oxygen saturation （SaO2）and arterial partial pressureof oxygen （ PaO2 ）after treatment，and lowerpartial pressure of carbon dioxide （PaCO2）（ P <0.05）.Compared with the control group，thestudy group hadhigher levelsof immunoglobulinA （IgA），immunoglobulin G （IgG），and immunoglobulin M（ 1gM ）aftertreatment（ P <0.05）.Compared with the control group，the study group had higher levelsof forcedvital capacity （FVC），forcedexpiratoryvolume inonesecond （FEVi），and FEV/FVC after treatment P<0.05 ）.There was no significant diference in adverse reactions（ P >0.05）.After treatment， the SF-36 scores of both groups increased，and that of thestudy group was higher.ConclusionThe combination therapy of bacterial lysate andbudesonide in AECOPDpatients can effectivelyreduce thelevels of variousserum inflammatoryfactors，improvebloodgas indicators，enhancepatient immune function，andpromotelung function recovery.Itis safe，reliable，and effective，with high clinical applicationand promotion value.

【Key words】Pulmonary disease，chronic obstructive;Bacterial dissolution products；Budgefu; Serum inflammatory factors;Pulmonary function; Blood gas analysis

COPD是慢性支气管炎、肺气肿引起的以气流受限为特征的肺部疾病，该病发病率较高，且逐年增长，以不完全可逆、呈进行性发展为特点。（剩余6376字）