基于多模态磁共振成像与Alberta卒中项目早期CT评分构建急性脑卒中溶栓治疗后短期预后预测模型

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Analysis a short-term prognosis prediction model for acute ischemic stroke after thrombolytic therapy based on multimodal magnetic resonance imaging and ASPECTS score Xing Anding， Xu Xuran，Fu Xiaoming. ， ，Jiangsu ，China

【Abstract】 Objective To explore the eficacy combining multimodal magnetic resonance imaging （MRI） and ASPECTS （Alberta Stroke Program Early CT Score）in constructing a short-term prognosis prediction model for patients withacute ischemic stroke （AIS）after thrombolytic therapy.MethodsA total 116AIS patients treated inour hospital from January2023 to June 2024 were analyzedanddivided intoa goodprognosisgroup （n=65） and a poor prognosis group n=51 ）according to short-term prognosis.The basic data，multiparameter magnetic resonance imaging resultsand ASPECTS scores the two groups were compared.The significantly diferent variableswere includedinthemultivariate Logisticregresion model，theshort-term prognosismodel was constructed，and thereceiver operator characteristic （ROC）curve was drawn toevaluate thediferentiationability the models.ResultsCompared with the good prognosis group，the poor prognosis group had a higher NIH strokescale（NIHSS） score，a higher proportion positive asymmetic prominent veins sigh（APVS），and a lower diffusion weighted imaging（DWI）-ASPECTS score （P<0.05） .Logistic regression analysis showed that NIHSS score， positive APVS，andDWI-ASPECTSscorewere independent influencing factors for the prognosis AIS patients（ P （20 <0.05）.The ROC curve showed that DWI-ASPECTS score had a high value in predicting poor short - term prognosis after thrombolytictherapy inAIS patients.The combinationNIHSSscoreand positive APVS could further improve the diagnostic value （Z=3.62， P<0.05 ）.ConclusionThe short-term prognosis prediction model forAISafterthrombolytic therapy，basedonmultimodal MRIandASPECTSscore，exhibitsgood diagnostic value and is crucial for guiding clinical decision-making.

【Key words】 Multimodal imaging;Diffsion-weighted imaging;ASPECTS score;Acute ischemic stroke;

急性缺血性脑卒中作为全球范围内最常见的脑卒中类型，其高致残率和死亡率不仅给患者个人及其家庭带来沉重的负担，也对公共卫生体系构成了严峻挑战。（剩余6837字）