挤压式细胞载药微流控装置设计

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关键词： 微流控载药装置； 挤压通道； 细胞模型； 流体分布器； 面应变； 流动颗粒跟踪中图分类号：TN492⁃34；TH778 文献标识码： A 文章编号：1004⁃373X（2025）12⁃0035⁃06

Abstract：In order to explore the potential of cells as carriers for drug loading， a physical extrusion microfluidic drug loading device with strong comprehensiveness is proposed for the efficient loading of various drugs into cells. The device is composed of the fluid distributor at the front end and multiple parallel extrusion channels at the back end， which can ensure good drug loading effect while having high sample flux and low blockage. The working mechanism of the device and the effect of flow rate on the cell extrusion effect were elucidated by means of the numerical study， and the size of the surface strain was used as a characterization of the cell extrusion effect. The results show that during the extrusion process， the loading effect increases with the increase of the extrusion speed. The extrusion chip can disperse cells more uniformly into different extrusion channels， and reduce partial channel blockage caused by large differences in cell distribution in multiple channels and the difference in flow velocity distribution between multiple channels， thereby reducing the difference in extrusion effect.

Keywords：microfluidic drug loading device; extrusion channel; cell model; fluid distributor; surface strain; flow particle tracking

0 引 言

微流控是一门涉及化学、流体物理、微电子、新材料、生物学和生物医学工程的新兴交叉学科。（剩余8857字）