振动强耦合对白蛋白光谱特性和功能性质的影响

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中图分类号：0431文献标志码：A

The impact of vibrational strong coupling on the spectral characteristics and functional properties of albumin

CHU Yahao， ZHANG Feng （School of Optical-Electrical and Computer Engineering， University of Shanghai for Science and Technology，Shanghai200093，China）

Abstract： The method of regulating the structural properties through vibrational strong coupling （VSC） is gradually becoming known to the public. The molecular system placed in an optical resonator may undergo changes in properties due to energy impact. Bovine serum albumin （BSA） is a commonly used protein，and its effects on different changes are particularly pronounced. When using a resonant cavity to adjust to a state resonantly coupled with water molecules， it affects the properties of BSA albumin in solution. By tuning the coupling strength between water molecules and cavity modes， it is observed that the binding effect of albumin itself changes correspondingly with the coupling strength. Furthermore， by employing three diferent characterization methods， significant changes in its spectral properties are discovered. This study is the first to confirm that the physical regulation of protein functional properties can be achieved through VSC technology， providing important insights for developing novel protein modulation strategies in the field of biomedicine.

Keywords： F-P microcavity; vibrational strong coupling; fluorescence detection

近年来，人们致力于寻找一种全新的改变分子材料化学性质的方法。（剩余6352字）