中老年慢性病伴抑郁病人抑郁症状的影响因素及网络分析

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AbstractObjective：Toinvestigatetheinfuencingfactorsofdepresivesymptomsamongmdleagedandelderlypatintswihhonic diseasesacompaniedbydepresion，toconstructasymptomntworktodentifycoreandbridgesymptoms，ndtotherebyeancethe effectiveessof interventionstargetingdepresivesymptoms.Metods：Data wereobtained fromthe2O2oChina HealthandRetirement Longitudinal Survey（CHARLS）.Depressonscreening wasconductedusingCenterforEpidemologic Studies DepressonScale（CE-D）. Linearregresionanalyseswereconductedtoidentifysignfcantpredictorsofdepressivesymptomsinthispopulation.Thesubgroup symptom Network Comparison Test（NCT）package was employed to examine diferences insymptom networksacrossubgroups. Results：Atotalof4874midleagedandelderlypatientswithhronicdseassacompanedbyepressonereincudedintheaalysis， aged between 45 and 97 years old.Patients aged 6O years and above constituted 54.7% of the sample.The mean CES-D score was 15.73±4.64 Thepatient's gender，thenumberofchronicdiseases，basicactivitiesofdailyliving，alcoholconsumption，exercisestatus， nightimesleepduration，napdurationandsocial interactionstatusweretheinfluencingfactorsoftheirdepresivesymptoms P<0.05 ） Networkanalysisrevealedthat"felingdepressed"exhibitedteghesttrengthcentralityandclosenesscentrality，hile"opefuln aboutthefuture"demonsratedthehighestbetweenssandbridgecentralityTerewereotatisticallysignificantdiferenceitersf network strength and overall structure among different subgroups P>0.05 ）.Conclusions： Depressive symptoms in middle-aged and elderlypatientsithchronicdiseasescompaniedbyepressonareiglyinterconected."Felingdepresedemergedastecore symptom，whereas"hopefulnessaboutthefuture"servedasakeybridgingsymptom.Gender，ealthstatusandlifestylefactorsere identifiedassignificant determinantsofdepressivesymptoms.Thesefindingssuggestthathealthcareprofessonalsmayimprove interventionoutcomesbyintegratingknowledgeofcoresymptoms，ridgesymptoms，andrelevantifluencingfactorsintoclinical practice.

Keywordsmiddle-agedand elderly;chronicdiseases;depression;network analysis;influencing factors

摘要目的：探索中老年慢性病伴抑郁病人抑郁症状的影响因素，并构建抑郁症状网络，以识别核心症状和桥梁症状，提高抑郁症状的干预效果。（剩余14134字）