基于卵母细胞质量下降的卵泡液多组学研究进展

中图分类号：R711.75 文献标志码：A DOI：10.11958/20253362

Abstract：In recent years，rapid advances in multi-omics technologies have substantially promoted metabolomic， proteomictranscriptomic investigationsfolicularfluid（FF），providing novel insights into molecularmechanism underlyingoocytequality deterioration.During processovarian function declinereproductive aging，hormone levels，energymetabolismlipidmetabolismcharacteristics inFFhaveundergone significantchanges.Itisacompanied by imbalanceininflammatory immune-related pathways.Avarietykeyproteins inFFnotonlyparticipatein ovulation，tissueremodelingsignaltransduction，butarealsocloselyrelatedtoqualityoocytesoutcome embryonicdevelopment.Thisreviewsystematically summarizes recent progressinFF-based multi-omicsresearch discusses itspotential appications inocytequalityassessment precisiondecision-making inasistedreproductive technologies.

Key words： folicular fluid; oocytes; metabolomics; proteomics; transcriptome; reproductive techniques，aisted

卵巢是女性生殖内分泌系统的核心器官，通过周期性排卵及分泌激素维持女性的生殖功能和促进第二性征的发育。（剩余12123字）