金黄色葡萄球菌在皮肤软组织感染中的耐药性及危险因素分析

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中图分类号：R978.1 文献标志码：A DOI：10.11958/20253187

Abstract：ObjectiveTo explore the pathogenic characteristics and drug resistanceof Staphylococcus aureus （SA） in patientswithskinandsofttissue infections （STIs），andtoanalyetheriskfactorsformethicilin-resistant Staphylococcus aureus （MRSA） infection.MethodsA totalof 110 patients who were hospitalized dueto SSTIsand whose secretionsor drainagefluidwereculturedasSA wereselected.Theclinicaldataofthepatientswerecolected，andthestatusof patients with SA infection，theantibioticssensitivityoftheSAstrainsandthecaryingrateofdrug-resistant genes werestatistically analyzed.MultivariateLogisticregresionwas used toanalyze theinfluencing factorsof MRSA infection in SSTIs patients. ResultsA total of 11O SSTIs-related SA isolates were isolated，among which27 isolates （24.5% wereMRSA.Compared withthemethicillin-sensitive Staphylococcusaureus （MSSA）group，the MRSAgroup hadahigherproportionofoutpatient antibiotic treatment before admission and mecA gene carriage rate （ P<0.05 ）. The resistance rate of SA to penicillin was the highest （94.5%） ，followedby erythromycin （58.2% ），and the resistance rate to rifampicin was the lowest （0.9 % ）. Resistance to linezolid，tigecycline，vancomcin，daptomycinandteicoplaninwasnotobserved.ComparedwiththeMSSA group，theMRA group had a higher resistance rate to oxacillin， tetracycline，minocycline and levofloxacin （ P<0.05 ）.Logistic regression analysis showed thatoutpatientantibiotic treatmentbeforeadmisionandfeverwere riskfactorsforMRSA infectionin SSTIs patients P<0.05 . ConclusionThe drug resistance spectrum of SA in SSTIs is diferent，and MRSA strains show extensive multi-drug resistance.STIs patients with outpatientantibiotic treatmentand feverbefore admissionaremorelikely to have MRSA infection.

KeyWords：Staphylococcus aureus;methicilin-resistant Staphylococcusaureus;anti-bacterial agents;skinandsoft tissueinfections;drugresistance;risk factors

近年来，随着临床抗菌药物使用的增加，耐药性问题已经成为全球公共卫生领域面临的重大威胁[1]。（剩余13002字）