膝关节腔内注射PRP联合间歇性低氧训练治疗早期膝骨关节炎的疗效及安全性

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中图分类号：R684.3 文献标志码：A DOI：10.11958/20253164

Abstract：ObjectiveToobserve theeficacyandsafetyof intra-articular injectionof platelet-rich plasma （PRP） combinedwith intermitent hypoxictraininginthetreatmentofearlykneeosteoarthritis （KOA）.MethodsAtotalof 220 patients with early KOA were enrolled and equally divided into four groups using arandom number table.The low oxygen groupreceived intermitent hypoxic trainingalone，thesodium hyaluronate+lowoxygengroupreceived intra-articular injectionofsodium hyaluronatecombinedwith intermitenthypoxic training，thePRPgroupreceived intra-aticularinjection of PRP alone and the PRP+low oxygen group received intra-articular injection of PRPcombined with intermitent hypoxic training.Patientsofallgroupswere treated contiuouslyfor6weeks.The numerical pain rating scale （NPRS）score， inflammatory pain mediators [C-reactive protein （CRP），tumor necrosis facto1 -α （TNF -α ），interleukin-17 （IL-17），5- hydroxytryptamine （ 5 -HT） and substance P]， oxidative stress indicators [superoxide dismutase （SOD），malondialdehyde （MDA）]，the knee ijuryandosteoartritisoutcomecores （KOOS），timedupandgotest （TUG）results，ndadverseractions were compared between the four groups.ResultsAfter treatment，NPRS scores，CRP，TNF- α ，IL-17，5-HT，substance P and MDA levels were decreased inorder in the low oxygen group，the PRP group，the sodium hyaluronate+low oxygen group and thePRP+lowoxygen group.SOD levels，thescores for pain，knee-relatedqualityoflife，symptoms，exerciseand recreation，activitiesof dailyliving and total KOOSscores were increased inorder inthese groups，whilethe TUG time decreased in order （all P<0.05 ）.There was no significant difference in the incidence of adverse reactions between the four groups （P>0.05 0.ConclusionApplying intra-articular injection of PRP combined with intermitent hypoxic training to treatearlyKOAcanefectivelyimprove theexpressonlevelsof inflammatorypainmediatorsandoxidativestresslevel， alleviate pain and enhance knee function and balance ability of patients，with high safety.

Keywords：osteoarthritis，knee；platelet-rich plasma;hypoxia;injection，intra-articular；sodium hyaluronate; intermittent hypoxic training

膝骨关节炎（KOA）属于退行性疾病，主要是关节软骨及关节滑膜出现增生、变性与损害所致，患者以膝骨关节疼痛及活动受限等表现为主，在老年人中具有较高发病率及致残率[1-2]。（剩余12553字）