复方苦参注射液联合靶向和免疫治疗对晚期肝癌的疗效观察
打开文本图片集
中图分类号：R735.3，R273 文献标志码：A DOI：10.11958/20252381
Abstract：ObjectiveTo observe the clinical eficacy of compound kushen injection combined with targeted and immunotherapyin patients withadvancedmalignant ivertumors.MethodsAtotalof1OOpatients with advanced primary liver cancer were divided into two groups according to the treatment methods：the control group（camrelizumab + lenvatinib， （204 n=50 ）and the observation group （camrelizumab + lenvatinib + compound Sophora flavescens injection， n=50 ）. Both groups receivedthree treatmentcycles.Theclinicaleficacy，traditional Chinesemedicine （TCM）syndromescores，Tlymphocyte subset levels，incidenceofadverse reactionsandsurvival timewerecompared beforeandafter treatment between the two groups.ResultsTheobjective responserate（ORR），disease control rate （DCR）andtotal effectiverate of TCMsyndrome score were significantly higher in the observation group than those of the control group （ P<0.05 ）.After treatment， TCM syndromescores forhypochondriacpain，abdominal distension，por appetite，jaundiceand fatiguewere lowerinthe observation group than those of the control group. Levels of CD4 F+ and the CD4+/CD8+ ratio were higher，while CD 8+ levels were lower in the observation group than those in the control group （ P<0.05 ）.The total incidence of adverse reactions was significantlylowerintheobservationgroupthanthatofthecontrolgroup.Mreover，bothprogresion-freesurvival（PFS） time and overallsurvival（OS）time were significantly longer in the observation groupthan that of thecontrol group （ P<0.05 ） ConclusionCompound Sophora flavescens injection combined with targetedand immunotherapy demonstratesgood clinical eficacyinpatientswithadvancedmalignantlivertumors.Itcanefectivelyimproveclinical symptoms，regulate immune function， prolong survival time and have good safety.
Key Words： liver neoplasms; Fu Fang Ku Shen Zhu SheYe;immunotherapy;molecular targeted therapy;comparative effectiveness research
2022年我国肝癌新发病例达36.77万，由于肝癌早期缺乏明显症状，起病相对隐匿，进展迅速，大多数肝癌患者确诊时已到中晚期，失去了根治性治疗的最佳机会[1。（剩余11406字）