光动力疗法联合超分子水杨酸治疗中重度痤疮患者的疗效分析

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中图分类号：R758.733 文献标志码：A DOI：10.11958/20252842

Abstract： ObjectiveTo investigate the effctof photodynamic therapy（PDT）combined with supramolecular salicylic acid on skin physiological parameters and serum levels of interferon- γ （IFN- γ ）and tumor necrosis factor -α （TNF- α ）in patientswith moderate to severe acne.MethodsTwo hundred patients with moderate to severe acne were selected and randomlydivided into theobservation group （treated with PDTcombined with supramolecularsalicylic acid， n=100 ） and the control group （treated with PDT alone， n=100 ）according to the random number table method.The clinical efficacy，lesion scores，skin physiological indicators， IFN- γ TNF- α levels and adverse reactions were compared between the two groups. ResultsThe total efectiverate was higher in the observation groupthanthat of thecontrol group （95.O% us.86.0%， P< 0.05）.Aftertreatment，thelesionsoresofomedones，papules，pustules，cysts，totallesionscores，skinoilontenandserum TNF- α levels were lowerin the observation groupthanthoseof the controlgroup，while the skin water content，pHvalue and serum IFN- γ levels were higher in the observation group than those of the control group （ P<0.05 ）.Therewasno significant difference in the incidence of adverse reactions between the two groups （ 11.0% Us. 12.0% ， P>0.05 ）. Conclusion PDT combined with supramolecular salicylicacid isefectiveinthe treatmentof moderate tosevereacne.Itcaneffectively improvetheconditionofskinlesionsandskinphysiological indicators，regulateserumlevelsof inflammatoryfactors，andhas good safety.

Key words：acne vulgaris;aminolevulinic acid; tumor necrosis factor-alpha; interferon-gamma; photodynamic therapy; supramolecular salicylic acid

痤疮好发于皮脂分泌旺盛区域，如面部、颈部、前胸和后背，是一种以粉刺、丘疹、脓疱、囊肿和结节为主要表现的慢性炎症性皮肤病1。（剩余10790字）