帕金森病患者血清ANGPTL2、NRG-1水平及临床意义

打开文本图片集

关键词：帕金森病；血管生成素样蛋白质类;神经生长因子类;ANGPTL2;NRG-1

serum ANGPTL2 and NRG-1 levels inPD patients.Logistic regression was used to analyze influencing factorsof PD. Receiveroperating characteristic （ROC）curves wereused to evaluate thediagnostic eficacyof both markers for PD. ResultsThe serum NRG-1 and education years of PDpatients were prominentlylower inthe observation group than those of the healthy group （ P<0.05 ），and the serum ANGPTL2 and proportion of PD family history were prominently higher in the observation group than those of the control group （ P<0.05 ）.The serum ANGPTL2 levels were higher in the cognitive impairment group than those of the non cognitive impairment group（ P<0.05 ），and NRG-1 prominently lower than the non cognitive impairment group （ P<0.05 ）.The serum ANGPTL2 levels increased successivelyin PD patients with H-Y stages 1-2，3and 4，and serum NRG-1 lvevels decreased successively （ P<0.05 ）. The serum levels of ANGPTL2 and NRG-1 were negatively correlated in PD patients （ r= -0.373， P<0.001 ）.Logistic regression analysis showed that elevated serum ANGPTL2 levelswere theindependent risk factors affcting theoccurrenceofPD，while high levelof NRG-1 wasan independent protective factor for PD（ P<0.05 ）.The area under the curve （AUC） of serum ANGPTL2，NRG-1 and their combined diagnosis forPDwas0.689 （95%CI： 0.645-0.733），0.717（95%Cl： 0.674-0.760）and0.768（95%Cl： 0.729-0.808）， respectively.Thecombined diagnosisof the twowassuperior totheindividual predictionofANGPTL2andNRG-1 （ZANGPTL2-combination=2.60 8 ZNRG-i-combination =2.017， P =0.009， P =0.044）. ConclusionPD patients have elevated serum ANGPTL2 levels andreducedNRG-1levels，withthe extentof these changes corelating with disease severity.Combinedtesting of these two indicators has important clinical value for the diagnosis of PD.

Key Words： Parkinson disease; angiopoietin-like proteins; nerve growth factors; ANGPTL2; NRG-1

帕金森病（PD）是一种常见的中枢神经系统退行性疾病1，发病率仅次于阿尔茨海默病，是第二大神经退行性疾病。（剩余9587字）