成人Still病活动度及复发风险与1F-FDGPET/CT代谢参数的相关性研究

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中图分类号：R593，R817.4 文献标志码：A DOI：10.11958/20252530

Abstract： Objective To investigate the correlation between the maximum standardized uptake value（ SUVmax ）of 18F- fluorodeoxyglucose（FDG）PET/CTandclinical diseaseactivityscoreaswellasrecurrenceriskofadult-onset Still'sdisease （AOSD）.MethodsA retrospective analysis was conducted on 17 patients with AOSD who underwent 18 F-FDG PET/CT at Tianjin Union Medicine CenterfromJune2019 toDecember 2023.Spearmanrank correlationanalysiswasperformed to analyze the relationship between SUVmax of lymph nodes，spleen and bone marrow with clinical disease activity score and laboratory parameters，and those between lymph node SUVmax and maximum short-axis diameter.Patients were divided into

the recurrent group and the non-recurrent group based on follow-up results.The diffrences in SUV max ， clinical disease activity score and clinical features were assessed between the two groups.ResultsAll 17 patients showed 18F- FDG uptake inspleen，bone marrowand lymph nodes.Additionally，2 patients （11.76% ）showed increased 18F -FDGuptakeinbilateral parotid glands （SUV 2.3，4.3），1 patient （ 5.88% ） showed increased 18F⋅ -FDG uptake in bilateral elbows，wrists，hand joints， max and left ankle （ SUVmax 3.9），and 1 patient （ 5.88% ） showed increased18F-FDG uptake in bilateral submandibular glands （ SUVmax 3.4）. The SUVmax of spleen and bone marrow were positively correlated with C-reactive protein levels（ rs value：0.575 and 0.549; both P<0.05 ）， while the SUVmax of lymph nodes was positively associated with their maximum short-axis diameter （ rs value： 0.522， P<0.05 ）. There was no significant correlation between disease activity score and SUV max in spleen， bone marrow，or lymph nodes （ rs value：-0.126，0.100 and 0.007， P>0.05 ）.TheSUV max of spleen in the recurrence group （9 patients）was5.20（4.45，6.05），which wassignificantlyhigher thanthatinthenon-recurrnce group8patients，3.80（2.70， 4.00）， P<0.05 ]. Conclusion1＆F-FDG PET/CT is avaluable tol for assessing AOSD disease activity and predicting disease recurrence， especially the SUVmax of spleen， which shows potential clinical value in predicting recurence.

Key words：Stil'sdisease，adultonset; positron-emission tomography;tomography，X-raycomputed;deoxyglucose; recurrence

成人Still病（adult-onset Still's disease，AOSD）是一种自身炎症性疾病，常累及多系统。（剩余12278字）