口腔鳞状细胞癌患者口腔微生物群的Meta分析

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中图分类号：R739.85 文献标志码：A DOI：10.11958/20252316

Meta-analysis oral microbiota changes in patients with oral squamous cellcarcinoma

（20 Δq Corresponding Author E -mail： 13902143866@163.com

Abstract：ObjectiveTo assess changes incomposition oral microbiota inoral squamous cell carcinoma （OSCC） by systematicreview and Meta-analysis.MethodsComputersearches wereconducted indatabasessuchasPubMed，Embase， CochraneLibrary，WebScience，Wanfang DataandCNKI togatherresearchon theoralmicrobiome OSCC.The search covered the period from theestablishment databases to March 252025.Literature wasscreened and data extracted according to literature inclusionandexclusioncriteria，and Meta-analysischanges intheabundancebacterial generain included studies wasperformedusing Stata17.0.ResultsAtotal23studiesinvolving1718participants wereincluded. These studies were divided into two categories：（1）case-control studies（n=14） and （2）cancer tisueversus paired paracancerous tissue （ n =9）.At the genus level，Fusobacterium was increased in abundance in OSCC patients （SMD=0.52， 95%CI：0.39-0.65， P<0.001 ） and cancer tissue （SMD=0.89，95%CI：0.55-1.24，P<0.001）.Porphyromonas was increased abundancein OSCC patients （SMD=0.17，95%CI：0.02-0.33，P=0.030） and cancer tissue（SMD=0.31，95%CI：0.10-0.53，P= 0.005）. Streptococcus was decreased in OSCC （SMD=-0.43，95%CI：-0.85--0.01， P =0.044） and cancer tissue （SMD=-0.66， （2号 95%CI：-0.96--0.37，P<0.001）. Conclusion Fusobacterium and Porphyromonas increase and Streptococcus decrease in OSCC patients and cancertisse，suggesting that oral flora dysbiosis is associated with the development OSCC.

KeyWords：mouth neoplasms; carcinoma， squamous cell; microbiota; Meta-analysis

口腔鳞状细胞癌（OSCC）是一种常见头颈部恶性肿瘤[1]。（剩余15360字）