nCD64、CRP联合LDH对儿童难治性肺炎支原体肺炎的诊断价值
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中图分类号：R725.6 文献标志码：A DOI：10.11958/20252783
Diagnostic value of the combination of serum neutrophil CD64， CRP and LDH in children with refractoryMycoplasmapneumoniaepneumonia
WANG E， ZHANG Pei， HUO Ying， JI Jialing， DING Ling， ZHANG Aiqing△ Pediatrics，theFourthAfliated 21Oo31，China Corresponding Author E -mail： njaiqing@njmu.edu.cn
Abstract：ObjectiveTo investigate the value of thecombined detection of neutrophil CD64 （nCD64），C-reactive protein（CRP）andlactatedehydrogenase（LDH）inthediagnosis ofrefractory Mycoplasma pneumoniae pneumonia （RMPP）in children.MethodsAtotalof 147children with Mycoplasma pneumoniae infection were enroledand dividedinto the RMPP group （ n=70 ） and the general Mycoplasma pneumoniae pneumonia group （GMPP， n=77 ） based on disease severity andtreatmentresponse.Theage，gender，white bloodcellcount （WBC）within24 hoursof admisson，serum procalcitonin （PCT），C-reactiveprotein（CRP）andlactatedehydrogenase （LDH）levelswerecolected inthestudyparticipants.The expresionlevel of nCD64 inperipheralbloodwas measured using flowcytometry.Multivariate Logistic regressonanalysis was conucted toidentifythe independentrisk factorsasociated with RMPPinchildren.Additionall，areceiveroperating characteristic （ROC）curve was constructedto assess the diagnostic performance of the combined detectionof nCD64，CRP and LDH for RMPP in children.ResultsThe RMPP group had a longer hospital stay than the GMPP group （ P<0.05 ） Levels of nCD64，CRPand LDH were significantly higher in the RMPP group compared to thoseof the GMPP group（ P< 0.05），and there werenosignificant differences in WBCandPCTlevels between thetwo groups.Multivariate Logistic regression analysis showed that elevated nCD64，CRPandLDH were risk factors for RMPP in children （ P<0.05 ）. ROC curve analysis revealed that the areas under thecurve （AUC）for nCD64，CRPand LDH in diagnosing RMPP were 0.817， 0.863 and O.805，respectively.The combined detection of three indicators for AUC was O.948.ConclusionThe levelsof nCD64，CRPandLDHin bloodofchildrenwithRMPPare higherthanthoseofchildrenwith GMPP.Thecombineddetection of the three indicators has a high diagnostic value for RMPP inchildren with Mycoplasma pneumoniae pneumonia.
KeyWords： pneumonia;mycoplasma;refractory diseases; C-reactive protein;neutrophil CD64; lactatedehydrogenase
肺炎支原体（Mycoplasma pneumoniae，MP）是全世界学龄儿童和青少年社区获得性肺炎最重要的病原体之一，每4～7年均会流行一次。（剩余9497字）
