短期饮食干预对肥胖合并糖代谢异常患者的影响研究

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【中图分类号】R589.25【文献标识码】A DOI：10.12114/j.issn.1007-9572.2025.0098

【Abstract】BackgroundRecent studies show that dietary interventions can induce remission of type 2 diabetes melitus （T2DM）inindividualswithoverweightorobesity，butrelatedevidencefrom Chinaremainslimited.ObjectiveTo evaluatetheclinical eficacyofashort-termdietaryinterventioninobesepatientswithabnormal glucosemetabolismandto examine its impact on hepatopancreatic fat content and pancreatic β -cell function.MethodsFrom March 202O to August 2022，60 obeseadults withabnormal gucose metabolismatending the ObesityClinicof theDeparmentof Endocrinology，Putuo Hospital，Shanghai UniversityofTraditional Chinese Medicine，wererandomizedtoalow-caloriebalanceddiet（CBD; n=30） or a meal-replacement diet （MRD; n =30） for 3 months.At baseline and post-intervention，group differences in changes in body composition，laboratoryindices，andimaging examinationwerecompared.ResultsGroups werecomparableatbaselineinsex distribution，body composition，laboratory variables，and imaging measures （all P>0.05 ）.After intervention，both groups exhibited significanreductionsfrombaselineinbodyweight （BW），bodymassindex（BMI），WC，odyfatpercentage （BFP），viscealata （VFA），subutaneousfatarea （SFA），fstingplasmaglucose（FPG）hourplasa glucoseduringoal glucosetoerancetst（ 2 hPG）， hemoglobin ΔΩ1c（HbA1c） ， HOMA- β ，HOMA-IR，liver FF， pancreatic FF，and lipid measures （ P <0.01）. Across both groups， mostglycemicinices，idprameters，uriccid（UA）alainaminotrasferase（LTndisuinsistanceiniceird significantly （ P <0.05），whereas HDL-C did not change significantly. Compared with the LCBD group，the MRD group achieved greater reductions in absolute and percentage BW，BMI， FPG，and VFA （ P <0.05）. ΔFPG was positively correlated with reductions inBW，WC，VFA，HOMA-IR，andliver FF（ P <0.05）.The changein HOMA-IR correlated positively with the change in liver FF （r=0.432， P =0.001）.ConclusionThe3-month dietary intervention effctivelyreduced BW，BMI， WC，hepatic fatcontent，and insulinresistanceinoeseadultswithabnormal glucosemetabolism，leading tosignificantimprovementsinabnormal glucose metabolism.

【Key words】 Obesity; Diet， reducing; Abnormal glucose metabolism; Pancreatic β cells; Correlation analysis

肥胖是糖尿病的重要危险因素，近年来我国的肥胖患病率逐年升高，据中国疾病预防控制中心发布的2023中国肥胖地图显示，按照中国人群的BMI分级，34.8% 的人超重， 14.1% 的人肥胖[1]。（剩余10870字）