β-原肌球蛋白在不同心肌病患者心肌组织中的表达及临床价值研究

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【中图分类号】 R542.2 【文献标识码】 ADOI：10.12114/j.issn.1007-9572.2025.0182

【Abstract】Backgroundβ-tropomyosin （TPM2） is a key structural protein that regulates muscle contraction，and itsabnormalexpressoniscloselyassociatedwiththedevelopmentofvariousdiseases.However，theexpresionpattesofTPM2 indifferenttypesofcardiomyopathiesremaiunclear.ObjectiveToinvestigatetheexpressonpaternsandclinicalrelevanceof TPM2in myocardialtisuesfrompatientswithhpertrophicrdiomyopathy（HCM），dilatedardomyopathy（DCM），doary arterydisease （CAD）.MethodsMyocardialtissuesamples werecollctedfrompatientswhounderwenthearttransplantationor septalmyectomyatTongjiHospital，TongjiMedicalColege，HuazhongUniversityofcienceandTechnologybetweenJaay 2016 and June 2021，including HCM （septal tissues， n =13），DCM （left ventricular tissues， n =48），and CAD （peri-infarct and non-infarct regions of the left ventricular， n=8 ）.Eightdonor hearts （left ventricular tissues， n=8 ，and septal tissues， n=6 ）were included ascontrols.Atissue microarraycontaining77 samples was constructed.TPM2 protein expression was assessedby immunohistochemistryanditsclinical relevance wasanalyzed.ResultsCompared tothedonor group，TPM2expression was significantly reduced in the septal tissue of HCM patients P <0.05）.In the HCM group，TPM2 expression in septal tissue was positively correlated with left ventricular end-diastolic volume （r=0.478， P =0.018）and left ventricular lateral wall thickness （r=0.475， P =0.040）.TPM2 expresson was alsosignificantlyreduced inthe left ventricular tissueof DCM patients compared to the donor group （ P <0.05）.Inthe CADgroup，TPM2 expressionlevels inbothperi-infarctandnon-infarctregionsshowednosignificant difference compared to controls （ P>0.05 . Conclusion TPM2 exhibits heterogeneous expression patterns across different cardiomyopathes.InHCMpatients，doneglationofTM2inseptalissueissignificantlyassociatedwithventricularodeling， suggesting that TPM2 mayplayacriticalrole inthe pathogenesis ofHCMand mayserve asa potential therapeutic target.

【Key words】 Dilated cardiomyopathy; Hypertrophic cardiomyopathy; Coronary artery disease; Tropomyosin 2

据《中国心血管健康与疾病报告2023》的数据显示，我国目前心血管疾病的患病率处于持续上升阶段，据估计约有3.3亿患者患有心血管疾病，其中心力衰竭患者约890万[1]。（剩余7773字）