早发冠心病患者共病情况及共病模式研究

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【中图分类号】R36【文献标识码】ADOI：10.12114/j.issn.1007-9572.2023.0890

【Abstract】BackgroundAlong with the continuous changeof lifestyle，the incidenceand hospitalization rate of coronaryheartdiseaseareincreasingandbecoming youngerinaverageage，patientsarealsogenerallsuferingfromotherchronic diseases，namelyfacing theproblemsofcomorbidities，butcurrentlytherelevantresearchinChinaisstillrelativelylacking. ObjectiveTounderstandtheprevalenceandpaternsofcomorbiditiesinprematurecoronaryheartdisease，andtoexplorethe correlationbetweencomorbiditis，inodertoprovidereferenceforarlyetectionndmanagementofomorbiditiesinpremature coronaryheartdiseaseinChina.MethodsElectronicmedicalrecorddataof5124 prematurecoronary heartdiseasepatients （males ⩽55 years old，females ⩽65 years old） admitted to the Department of Cardiovascular Medicine，Norman Bethune Second HospitalofJilinUniversityfrom2O10to2O22werecollectedandanalyzedtodeterminethecurrentstatusofcomorbiditiesin prematurecoronaryheartdisease.SPS26.OstatisticalsoftwareandPython3.11.Oereused，alongwiththeApriorialgoritm，to mine strong assciation rules for premature coronary heart disease and explore thecomorbidity patterns.ResultsThe top threecomorbidities withthehighestprevalenceinpatientswithprematurecoronaryheartdiseasewerehypertension（37O7cases， （204 72.35% ），dyslipidemia （2134 cases， 41.65% ），and diabetes （1 811 cases， 35.34% ）. Thirty five notable comorbidity patterns observedamong the13chronicdiseases.Thebinarycomorbiditypatternofprematurecoronary heartdisease takes "hypertension" asthecorecomorbidity，whichcanbeaccompaniedbyanemia，idneydisease，stroke，etc.Theterarycomorbiditypetakes "anemia + kidney disease"as the corecomorbidity，which may beaccompanied bydiabetes and lungdisease，etc.Thequaternary comorbiditypattern takes "diabetes + hypertension" as the core comorbidity，which may be accompanied by stomach disease，liver disease，etc.According totheresultsofteasoiationruleandcusteranalysis，hypertension，diabetes，dylipidemiaanemia， andkidneydiseaseallhadsignificantcomorbidityrates，withacomplexcomorbidityrelationship.ConclusionThepredominant comorbiditydiseaseinthepopulationofprematurecoronaryheartdiseaseishypertensionndthecomorbiditypateof "aemia + （20 kidney disease" of early-onset coronary heart disease can be examined in future studies.

【Key Words】Premature coronary heart disease; Comorbidity mode; Asociation rules; Clustering analyse; Electronic medical record

早发冠心病（premature coronary arterydisease，PCAD）是以年轻人群发生冠心病为临床特征的一类疾病，一般定义冠心病发病年龄为男性 ⩽55 岁，女性⩽65 岁［1］。（剩余11888字）