铁死亡在血液肿瘤中的研究进展

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本文引用：，．铁死亡在血液肿瘤中的研究进展[J]．医学研究与教育，2025，42（6）： 基础医学·1-14.DOI：10.3969/j.issn.1674-490X.2025.06.001.

中图分类号：R733 文献标志码：A文章编号：1674-490X（2025）06-0001-14

Advances on ferroptosis in hematological malignancies

WUTing，ZHOUYue （Faculty ofMedicine，DaliUniversity，Dali671OOO，China）

Abstract： Hematological malignancies are a group of heterogeneous diseases originating from the hematopoietic and lymphatic systems，characterized fundamentally by malignant clonal proliferation and differentiation arrest.Clinically，there are often significant challenges of poor prognosis and high risk of recurrence.Ferroptosis，an iron-dependent form of regulated cell death driven by lipid peroxidation， has been confirmed to be closely related to the pathogenesis， progresson，and therapeutic response of hematological malignancies. This article systematically reviews the molecular mechanisms of ferroptosis. It focuses on the research developments of hematological malignancies represented by leukemia，multiple myeloma，myelodysplastic syndromes，and lymphoma through the regulation of ferroptosis-related genes and pathways in order to provide a theoretical foundation for a deeper understanding of the disease process and the development of targeted treatment strategies.

Key words： ferroptosis ； hematological malignancies ； pathological mechanism; targeted therapy

血液肿瘤是一类起源于血液、骨髓及淋巴组织的异质性肿瘤，因其高度异质性及易产生治疗耐药性，临床治疗面临严峻挑战[1。（剩余28745字）