基于网络药理学探讨益气活血通脉方治疗反杓型高血压的分子机制
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AbstractObjective：ToexplorethepotentialmechanismofYiqiHuoxueTongmaiFormulaforthetreatmentofreverse-dipper hypertensionbasedonnetworkpharmacologyMethods：ThebioactivecomponentsofYiqi HuoxueTongmaiFormulawerescreenedand theirtargetswerepredictedbyusingtheChineseMedicineSystemsPharmacologyDatabaseandAnalysisPlatform（TCMSP），AA TCM Database，PubChemdatabaseand Swiss Target Predictiondatabase.The DisGeNET，GeneCardsandOMIMdatabases were apliedtocollecterelevanttargetsofreverse-dipprhypertensionTheVenny2.1softarewasusedtomapthetargetsoftheYiqi HuoxueTongmaiFoulaandeverse-dipperhypertesionbtaintheommontargetsofrugsanddiseases，dratheVeiagra， constructthe"drug-component-ntersectiontarget"networkdiagramandtobtaintecoreactiveingredients.Theprotein-protein interaction（PPl）networkwasconstructedusingtheSTRINGdatabaseandCytoscape3.9.1softwaretoscrenandobtainthecore targets.TheDAVIDdatabasewasusedforgeneontology（GO）functionalannotationandKyotoEncyclopediaofGenesandGenomes （KEGG）pathwayenrichmentanalysisofcommontargetgenesfordrug-diseaseResuts：Atotalof109compoundsand1256targets werescreenedoutfromtheYiqiHuoxueTongmaiFormulaincluding1231targetsforreverse-iperhypertension13intesection targetsand11keytargets.TheresultsofGOenrichmentanalysisshowedtherewere1202biologicalprocesses，125cellar componentsnd225molecularfunctios.KGGenrichmentanalysisincuded189sinalingpathways.Thepotentialagetsiledin theinterventiooftiHouegaolafoveertesiodulin）tekin6r protein53（TP53），transcriptionactivator3（ST3）andtyrosinekinase（SRC）.Teelatedsignalingpathwaysincludedteadaced glycationendproductsandteireceptors（AG-AGE）sinalingpathayinabeticomplicatios，tepoia-iduciblefacto-） signalingpatwaythcaciusigningpathayteposphatidyliositol3-kinase-proteininaseB（P3K-AKT）signalingpatayte mitogen-ativatedproteinkinase（MAPK）signaingpatwayap1signalingpathwaysprolactinsinalingpathwaysandrelainiing pathways.Conclusion：YiqiHuoxueTongmaiFormulafortreatingreverse-dipperhypertensionshowedthecharacteisticsandadvantages fmutipleomponents，utipeagetsndmutplepathwaysanditouldseeasanimportantresearchbasisforfurtrexploingthe active substances and mechanism ofaction of Yiqi Huoxue Tongmai Formula in treating reverse-dipper hypertension.
Keywordsreverse-dipperhypertension;Yiqi HuoxueTongmai Formula; network pharmacology;target;molecularmechanism
在我国，高血压患病率及心脑血管并发症发生率在慢性非传染性疾病中居首位，是引发致命并发症的主要危险因素之一[1]。（剩余16483字）
