基于数据挖掘、网络药理和分子对接研究高血压合并糖尿病(阴虚型）的用药规律及作用机制

打开文本图片集

MedicationRegularityMechanismHypertensionComplcatedwit Dabetes Melitus（YinDeficencyType）BasedonDataMining， Network Pharmacology， Molecular Docking SONGJiayuan1，LIShuling²，MA Chun²，WANG Yu²，YANGLihua²

1.Westem

，Hosangn

3. Medicine

Corresponding AuthorYANG Lihua，E-mail： ylh7239@126.com

AbstractObjective：Toexplorethemedicationrulesactionmechanismstraditionalmedicineprescriptionsforpatints withhypertensiondiabetesmeliuswitndeficiencytypeMethods：Aprescriptiondatabasewasonsructedfortatisticalanalysis thefrequencycategoryatureflavor，tomeridiantropismtraditionalmedicinedeepminingsuchasuster analysis，ssiationaalysisndomplexetworkaalysis，tommaetoredrugpisrtheitersectiotargtfdrugpair disease，protein-proteininteractions（PPl）networkwasconstructedcoretargetwasscreenedforgenentology（OKyto EncyclopediaGenesndGenomes（KG）ecmentanalysis.e"tradionalCineeedicinomponenttargepathaetork wasconstructedtoreencorecmponntstecorecomponentsndoretargetseredckedespectivelyesutsAtotal54 arileswereiudedvoing63rousradioalCinsemeicieprescritios，ontainng4indsiesebih cumulativefrequency786.ThetopthreefrequentlyuseddrugswereRehmanniaglutinosa，Lyciumbarbarum，Uncaria rhynchophyll.Teproportiontonifyingdrugsastheghestonamongthem.heirmainfavorsweresweetcoldteymainly affecthelivermeridianAssociationruleanalysisidentfied1coredrugpaircombinationsclusteranalysisyielded4combinatios.e coredrugpaifcaoaiotidiserteditscttouhympotsheetimferold targetingP53，interlekin-6（L6roteininaseAKT）epideralgrowthactoreceptorEGFR）ndpartcipatedinpthwa includingTumorecosisfactor）nterkin-177）dacedglyatiodproductsAGE）eceptorfordvancdatio products（RAGE），mitogen-activatedproteinkinase（MAPK）.MoleculardckingshowedthatHSP90AB1-yohimbinewasthecoplex withthehighestbindingafityocluson：NourishingYinsuppessngYangisthemaintreatmentmethdforYindeficencytype hypertensionomplicatedwitdiabetesmeliusUncar-ConchaHaliotiscanexertistherapeuticefecttroughmutiplecoonts， targets， pathways，this study willprovidea reference scheme forclinical treatment.

Keywordshypertension; diabetes melitus;data mining; network pharmacology; molecular docking

糖尿病是一种在遗传及环境因素共同作用下发生的以血糖升高为典型临床特征的内分泌代谢性疾病1。（剩余8905字）