基于加权基因共表达网络分析筛选动脉粥样硬化铁死亡相关Hub基因

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Screning HubGenesAssociatedwithFerropsisinAtherosclerosis UsingWeightedGeneCoexpressonNetworkAnalysis WANG Miaoqian1，MA Mingfeng2

1. Colege ，；2. Province/

Afiliated ， O322oo

Corresponding AuthorMA Mingfeng，E-mail： mamingfeng106@ sina.com

AbstractObeteTdentifyonfopateddiretiallexpessdnesiseosisAusingti analysis.Methods：BiinformaticaalysiswasconuctedinGSE12288GSE9710andGE28829.The"limmapackagewasused identifydiferentialyexpressedgnes（DEGs）Difrentkindsenrichmentanalyseswereperformedtindoutterelevantpathays. WeightedcorelationnetworkanalysisWGCNA）wasperfoedconstructcoexpressionnetworkexplremarkercorelationsand identifymportantinteractinggenemodulescorelatedwitSCscapewasusedvisuaieferropsisrelaedgenesandomenon codingRNAsinteractionnetwork.CIBROSORTwasusedevaluateabundance immunocytes，revealingtheefect immune responseinAus：itrosisedifrellpredsDseauchriigt）， glutamatereceprsubunit 3（GRIA3），Promin-2（PROM2），interleukin-1β（IL1β）andsoon.Geneonlog（GO）analysisandGeneSet EnrichmentAnalysis（GSEA）foundpathwayssuchasgulatiohelialcellprliferationmembraneraftndvasuladothelia growthfacr（VEGF）pathwayenrichedinthisdiseases.Regularynetworkandimmunocyteinfitrationabundanceanalysiswere performedevaluatetheunderlyingmechanisminAS.Conclusion：ThityDEGsassociatedwithferopsiswerefoundinASand corelatedwitpathologicalprogresiontedisease.Tepathogenesisandpotentialmoleculartargetsthediseasewerediscused forpotentialtreatmenttargetsinthefuture.Howeverteunderlyingpathogenesisandpotentialmoleculartargetsstiledore comprehensive and in-depth studies.

sywordsatherosclerosis; ferropsis; Hub gene; gene co-expression; bioinformatics analy

动脉粥样硬化（atherosclerosis，AS）是一种主要影响大中型动脉的慢性炎症性疾病[13]，是由氧化型低密度脂蛋白（oxidized lowdensity lipoprotein，ox-LDL）胆固醇在动脉壁中积聚，从而引发一系列连锁炎症反应。（剩余18310字）