SSRIs抗抑郁作用与肠道菌群的相互影响研究进展

中图分类号R964 文献标志码A 文章编号 1001-0408（2025）20-2599-05

DOI 10.6039/j.issn.1001-0408.2025.20.20

Research progress on the interactions between the antidepressant effects of SSRIs and gut microbiota SHI Lingyi，ZHOU Xiangjun，JIANG Ying，ZHU Haohao（Dept.of General Psychiatry，the Afiliated Mental Health Center of Jiangnan University，Jiangsu Wuxi ，China）

ABSTRACTSerotonin-selectivereuptakeinhibitors（SSRIs），aswidelyusedantidepresantsinclinical practice，exhibit significantindividualdiferencesinantidepresanteficacyGutmicrobiotaplaysanimportantroleinthedevelopmentand progresionofdepression，andtheuseof SSRIs exertsasignificantimpactonthegut microbiotaofpatients withdepresionBased onthis，thisaticlereviewsteresearchprogresonteinteractionsbetweentheantidepressnteectsofRIsandgutmicoiota. IthasbeenfoundthatSSRIscaninfluencethediversity，abundance，andfunctionofthegutmicrobiota directlyorindirectly. Conversely，thecompositionofthegutmicrobiotaanddierencesinitsfunctionalmetabolicpathways，andotherfactors，canin turnafcttheantidepressantefectsofSSRIsTherefore，inclinicalpractice，gutmicrobiotadiversitycanbeutilizedasa predictiveindicatorfortheantidepressntefectsofSSRIs.ProbioticscanbeemployedasanadjucttherapyalongsideSRIs，and dietaryadjustments，aswellasfecal microbiotatransplantation，canbeusedtoenhancethetherapeuticeficacyof SSRIs.Inthe future，large-scale，multicenterclinical studiesshouldbeconducted，enrollingabroadlyrepresentativecohortof patientswith depression，touncover thetrue association betweentheantidepressant efectsof SSRIsandgut microbiota，therebyopeningup more effective avenues for the comprehensive treatment of depression.

KEYWORDSserotonin-selective reuptakeinhibitors；gut microbiota;depression；mechanismof action；clinical application

5-羟色胺选择性再摄取抑制剂（serotonin-selectivereuptakeinhibitors，SSRIs）可抑制突触前膜对5-羟色胺（5-hydroxytryptamine，5-HT）的再摄取作用，增加突触间隙中的神经递质浓度，从而改善抑郁症状；相较于三环类抗抑郁药，其具有更简单的药理学特征及更高的安全性。（剩余12179字）