非离子型碘造影剂致患者死亡43例文献分析

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中图分类号 R981+.1；R969.3 文献标志码A 文章编号 1001-0408（2025）13-1655-06

DOI10.6039/j.issn.1001-0408.2025.13.17

Literatureanalysisof43cases of deathcausedbynon-ionic iodinecontrastmedia

TIAN Hongxing，TIAN Hongyan，LI Tao，YAN Wan，LI Yue（Dept. of Pharmacy，Guiyang Maternal and Chilc Health Care Hospital，Guiyang 550003，China）

ABSTRACTOBJECTIVEToanalyze thecharacteristicsandinfluencing factorsof patientdeathscaused bynon-ioniciodine contrastmediaandproviderecommendations forsafemedication，therebyprovidingreferencesforclinicalappication.METHODs Reportsoffatalcasesassociatedwithnon-ioniciodinecontrast mediawereretrieved fromdatabases includingCNKI，Wanfang， VIP，PubMed，CochraneLibrary，Webof Science，Embase，and SpringerLink.Statistical analysis was performed toexamine the characteristicsandinfluencingfactorsofthesefataities.RESULTSAtotalof43deathscausedbynon-ioniciodinecontrastedia were retrieved，including 21 males （ 48.84% ）and22females 51.16% ）.The majority of deaths occurred in 32 patients aged 51-85 years old （74.42%） ）.The original diseases were mostly cardiovascular and cerebrovascular diseases（ 30.23% ）and digestive system diseases（ 30.23% ），and only 2 cases had a clear allergy history（ 4.65% ）.Among the lethal drugs，iohexol（ 37.21% ）and iopromide（ 25.58% ）accounted for the highest proportions. The main causes of death were anaphylactic shock！ （51.16% ），cardiac arrest （11.63% ），and pulmonary edema（ 11.63% ）； 48.84% of the patients’ADR occurred within 30 minutes，and 62.79% of the patients diedonthefirstday.It mainly involvedthecirculatory system，nervoussystem andrespiratorysystem，andthemain manifestations were breathingdificulties，loworundetectablebloodpressure，vomiting，etc.CONCLUSIONSThelethaldrugsof non-ioniciodinecontrastmediaaremainlyiohexolandiopromide.Theadversereactionsocrquickly.Clinically，itisnearyto focusonmonitoringthevitalsignswithin 3Ominutesaftermedication，andtimelytreatmentof symptomssuchas dyspneaand abnormal blood pressure to reduce the risk of death.

KEYWORDSnon-ionic iodine contrast media；death；literature analysis；adverse drug reaction

随着医学影像技术的快速发展，含碘造影剂已被广泛应用于计算机断层扫描（computed tomography，CT）、冠脉造影及尿路造影等领域。（剩余10594字）