药源性低纤维蛋白原血症临床特征及危险因素的文献分析

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中图分类号R969.3 文献标志码A 文章编号 1001-0408（2025）13-1648-07

DOI 10.6039/j.issn.1001-0408.2025.13.16

Literatureanalysisofclinical featuresand risk factorsof drug-induced hypofibrinogenemia

WEN Xiao，CAI Le，GAO Ao，ZHU Man（Dept. of Pharmacy，Medical Support Center，PLA General Hospital. Beijing 100853，China）

ABSTRACTOBJECTIVETo exploreclinicalcharacteristics andrisk factorsof drug-induced hypofibrinogenemia，providinga referenceforrationalclinicaldruguse.METHODSRetrospectivecaseanalysesliteratureondrug-iducedhypofibrnogenemiawere collected fromdomesticandinternationaldatabases fromtheirinceptiontoDecember31，2024.Thepatients’gender，age， fibrinogen（FIB）levelsbeforeandaftertreatment，drug types，theincidenceof drug-inducedhypofibrinogenemia，timeof occurrence，bleedingrates，clinicalmanifestations，riskfactors，andprotectivefactorswereallanalyzedRESULTSAtotalf40 retrospectivecaseanalysisstudieswereincluded，involving17313patients.Patient agerangedfromO.83to78.4Oyears，with males accounting for 16.90%81.00% .The involved drugs comprised 5 categories and 13 specific agents，including tigecycline， snakeveomhemocoagulase，tocilizumab，andalteplase，etc.Theincidenceofdrug-induced hypofibrinogenemiarangedfromOto 100% ，occurring between 2 hours and9months after drugadministration，andFIB levelsrebounded inmost patientsafterdrug discontinuation. The bleeding rate varied from 0% to 91.30% ，including epistaxis，airway bleeding，gastrointestinal bleeding，and cerebralhemorhage.Riskfactors includedhighdrugdosage，prolongedtreatmentdurationabdominalinfection，advancedage， andlowbaselineFIBlevels.Protectivefactors wereonlymentioned in studieson tigecycline，including skinandsofttisue infectionsandhighbaselineFIBlevels.CONCLUSIONSDrug-inducedhypofibrinogenemiaiscommonlyassociatedwith tigecycline，hemocoagulase，andtocilizumab.Itsclinicalfeaturesvarydependingonthedrug，andriskfactorsincludehighdrug dosage，prolonged treatment，lowbaselineFIBlevels，andadvancedage.Forhigh-riskmedications，individualizedmedication management and monitoring of FIB levels are recommended.

KEYWORDShypofibrinogenemia；drug-induced；fibrinogen；adversedrugreactions；clinical features；riskfactors；literature analysis

纤维蛋白原（fibrinogen，FIB）是一种仅在肝脏合成的血浆糖蛋白，在血栓的形成与稳定中发挥着核心作用。（剩余14070字）