PFKFB成员在泛癌的表达及其与肿瘤免疫和药物敏感性分析

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【关键词】果糖-2，6-二磷酸酶（PFKFB）；免疫亚型;药物敏感性；泛癌 中图分类号：R730.5 文献标志码：A DOI：10.3969/j. issn.1003-1383.2025.12.002

【Abstract】ObjectiveTo explore theimmuneanddrugsensitivityregulatoryefectsof fructose-2，6-diphosphatase （PFKFB）ontumors，and toanalyze the gene expresion，immune subtypes，anddrug sensitivityofPFKFBfamilymembers， so asto provide new knowledgeforcancer treatment targets.MethodsData for33cancertypes，including RNA-seq，clinical phenotypes，and immune subtypes，were downloaded from the cancer genome atlas （TCGA）.Cell data and RNA sequencing data were obtained from CellMinerand processed using PerlandRlanguagesandtheir packages.Wilcoxon test wasused to processand analyze the sequencing data downloaded from the TCGA database.ResultsTheexpressionof PFKFB familymembers exhibited different heterogeneityindiferentcancers.PFKFB1，PFKFB3，andPFKFB4predicted poor prognosis in patientswithmultiplecancers，andallmembers wereassociated with immune response.Research had found that PFKFB2 and PFKFB4 might promote drug resistance incancer cels. ConclusionBased on gene expresion and its coreltion with immune infiltrationand tumor microenvironment，membersof thePFKFB family have specificroles in each type of cancer，and PFKFB2 and PFKFB4 may serve as targets for cancer therapy.

【Keywords】fructose-2，6-biphosphatase（PFKFB）；immune subtype；drug sensitivity；pan-cancer

缺氧作为肿瘤的重要特征之一，在肿瘤细胞的生长、侵袭和转移中起着重要作用[1]。（剩余5761字）