重复经颅磁刺激对帕金森病冻结步态影响的Meta 分析

·科研论著·

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Effect of repetitive transcranial magnetic stimulation on frozen gait in Parkinson's disease：a

Meta-analysis

YU Qiongge，ZHAO Hui，SUN Dan，LONG Yu，WEN Yuhang，JIA Qiufeng，YU Yufeng

School of Nursing，Chengdu University of Traditional Chinese Medicine，Sichuan 610075 China

Corresponding Author YU Yufeng，E-mail：19902026@cdutcm.edu.cn

Abstract Objective： To evaluate the effect of repetitive transcranial magnetic stimulation on frozen gait of patients with Parkinson's disease. Methods： RCTS on the use of repetitive transcranial magnetic stimulation to intervene in the frozen gait of Parkinson's patients were retrieved from CNKI，WanFang Database，VIP，Chinese Medical Journal Full⁃Text Database，PubMed，Web of Science，EMbase， and the Cochrane Library. The search period was from the establishment of the database to August 15， 2024. The 5.1.0 version of the Cochrane Collaboration quality assessment tool was adopted to evaluate the quality of the included literature.RevMan 5.4 software was adopted for data extraction.Stata 16.0 software was adopted for publication bias assessment.Results：A total of 14 RCTs were included， involving 664 patients with Parkinson's disease. Some literature did not report the concealment and blinding of intervention program allocation.The results of the Meta⁃analysis showed that repetitive transcranial magnetic stimulation could reduce the FOG ⁃Q score（SMD ， 95%CI ， P<0.000 1 ），TUGT time（SMD =-0.68 ， 95%CI -1.22 ⁃ -0.13， P=0.01Γ and UPDRS Ⅲ score（ SMD=-0.7Ω ， 95%CI -1.19--0.38 ， P=0.0002 ） of Parkinson's patients. Conclusion： Existing evidence shows repetitive transcranial magnetic stimulation can improve the freezing gait of patients with Parkinson's disease， but it is limited by the quantity and quality of the included literature. The research results still require high ⁃ quality and large ⁃ sample studies to verify the optimal intervention conditions and long ⁃ term efficacy.

Keywords Parkinson's disease; frozen gait; transcranial magnetic stimulation; Meta⁃analysis; evidence⁃based nursing摘要 目的：评价重复经颅磁刺激对帕金森病病人冻结步态的影响。（剩余11552字）