腹腔镜根治术对早期胆囊癌患者围手术期指标及免疫应激反应的影响

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摘 要 目的：分析腹腔镜根治术对早期胆囊癌患者的治疗效果。方法：将88例早期胆囊癌患者随机分为对照组（n=44）和观察组（n=44）。对照组行开腹根治术，观察组行腹腔镜根治术，对比2组术前及术后1个月的围手术期指标、免疫应激反应、生活质量、并发症发生情况。结果：观察组术中出血量、手术时间、胃肠功能恢复时间和住院时间等各项围手术期相关指标优于对照组，术后的肾上腺素、去甲肾上腺素、皮质醇、白介素-4水平低于对照组，干扰素-γ水平与GQOLI-74内各维度评分高于对照组，并发症发生率低于对照组（均P

关键词 早期胆囊癌 腹腔镜根治术 免疫应激反应 生活质量 并发症

中图分类号：R730.56； R735.8 文献标志码：B 文章编号：1006-1533（2024）03-0047-04

引用本文 沈振梁， 黄德玉. 腹腔镜根治术对早期胆囊癌患者围手术期指标及免疫应激反应的影响[J]. 上海医药， 2024， 45（3）： 47-50.

Effect of laparoscopic radical surgery on perioperative indicators and immune stress response in patients with early-stage gallbladder cancer

SHEN Zhenliang1， HUANG Deyu2

（1. Department of General Surgery； 2. Department of Radiotherapy， the Second Hospital of Longyan City， Fujian Province， Longyan 364000， China）

ABSTRACT Objective： To analyze the therapeutic effect of laparoscopic radical surgery in patients with early gallbladder cancer. Methods： Eighty-eight patients with early gallbladder cancer were randomly divided into a control group （n=44） and an observation group （n=44）. The control group underwent open radical surgery and the observation group underwent laparoscopic radical surgery. The perioperative indexes， immune stress response， quality of life， and the incidence of complications were compared between the two groups before and 1 month after surgery. Results： The perioperative indicators such as intraoperative bleeding， the time for operation and gastrointestinal function recovery and hospitalization were better in the observation group than the control group. The postoperative levels of epinephrine， norepinephrine， cortisol and interleukin-4 and the incidence of complications were lower， while the levels of interferon-gamma and the scores of dimensions in the GQOLI-74 were higher in the observation group than the control group （all P

KEY WORDS early-stage gallbladder cancer； laparoscopic radical surgery； immune stress response； quality of life； complication

膽囊癌是胆道系统最常见的恶性肿瘤类型，其发病率在所有消化系统恶性肿瘤中位列第6 位[1-2]。（剩余4455字）