秀丽隐杆线虫在中药抗衰老研究中的应用

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〔摘要〕 中药作为一种毒副作用少的天然物质，在抗衰老研究领域有巨大的潜力。本文就近年来以秀丽隐杆线虫为动物模型，探索中药通过对多种信号通路及衰老相关基因的调控发挥抗衰老作用的研究进行综述，为深入探索中药延缓衰老的生物活性和分子机制提供理论依据和试验参考。

〔关键词〕 中药;衰老;抗衰老;秀丽隐杆线虫;衰老动物模型;信号通路;作用机制

〔中图分类号〕R285.5       〔文献标志码〕A        〔文章编号〕doi：10.3969/j.issn.1674-070X.2022.09.029

Application of Caenorhabditis elegans against aging in traditional Chinese medicine

LIU Jin， ZHOU Lei， BU Lanlan， CHENG Shaowu ZHENG Xilong

（Hunan University of Chinese Medicine， Changsha， Hunan 410208， China）

〔Abstract〕 Traditional Chinese medicine， as the natural substance with low toxic and side effects， has great potential in anti-aging research. This paper reviews the recent studies on the anti-aging effects of traditional Chinese medicine through the regulation of various signaling pathways and aging-related genes using Caenorhabditis elegans， so as to provide theoretical basis and experimental reference for further exploration of the biological activities and molecular mechanisms of traditional Chinese medicine in delaying aging.

〔Keywords〕 traditional Chinese medicine; aging; anti-aging; Caenorhabditis elegans; aging animal model; signaling pathway; mechanism of action

衰老是一个复杂的、多因素相互作用所决定的必然的生理过程[1]，并且伴随多种疾病的发生，如代谢性疾病[2]、心血管疾病[3]、呼吸系统疾病[4]、自身免疫性疾病[5]和神经系统疾病[6]等。（剩余17317字）