中医药治疗溃疡性结肠炎的信号通路研究进展

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中图分类号：R574.62文献标志码：A 文章编号：1003-9783（2025）02-0299-08

doi：10.19378/j.issn.1003-9783.2025.02.017

Research Progress on the Signaling Pathway of Traditional Chinese Medicine in the Treatment of Ulcerative Colitis

YANG Hongjuan’，LI Yanlong²，TIAN Xudong²，CHEN Zhendong'，WANG Peixin’，HAI Jie'，ZHANG Zongbo（1.Gansu University of Traditional Chinese Medicine，Lanzhou 73Oooo Gansu，China；2.Gansu Provincial Hospitalof Chinese Medicine，Lanzhou 73Oo50 Gansu，China）

Abstract：Ulcerative colitis （UC）is a chronic，nonspecific inflammatorydisease limited to thecolorectal mucosa and submucosa，which recurs repeatedlyand is diffcult to cure.In recent years，an increasing numberof studies have shown that Chinese herbal monomers and compound recipes arecapable of regulating Tol-like receptor 4/nuclear transcription factor -κB （TLR4/NF- κ B），nucleotide-binding oligomerisation structural domain-like receptor protein 3 （NLRP3），Janus kinase/transcription activating factor 3（JAK/STAT3），phosphatidylinositol 3-kinase/protein kinase B（PI3K/ Akt），neurogenic site gap homologue（Notch），adenylate-activated protein kinase/mammalian target of rapamycin （AMPK/m-TOR），signaling pathways to inhibit inflammatory responses，oxidative stress，and apoptosis， as well as repairing intestinal barrier to reduce UC symptoms and improve intestinal function.The paper systematically summarizedthe contentof the mechanism of traditional Chinese medicine（TCM）in the treatment of UC basedon the signaling pathway，with a view to providing a new theoretical basis for the treatment of UC with TCM.

Keywords： Ulcerative colitis； Chinese herbal monomers；compound recipes； signaling pathway；mechanism of action

溃疡性结肠炎（UC）是一种慢性非特异性的肠道炎症性疾病，以直肠和结肠的浅表溃疡为特征，容易增加患癌的风险。（剩余18561字）