柚皮苷对破骨细胞作用的机制研究进展

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中图分类号：R285.5文献标志码：A 文章编号：1003-9783（2025）02-0294-05

doi： 10.19378/j.issn.1003-9783.2025.02.016

Research Progresson the MechanismofNaringin on Osteoclasts

HE Ziyi'，JIN Huan¹，MA Chen²，SHEN Lin2 ，SHUAI Bo1，2 （1.School of Sports Medicine，Wuhan Sports University，Wuhan 430079 Hubei，China；2.Department of Integrated Traditional Chinese and Western Medicine， Union Hospital，Tongji Medical College，Huazhong Universityof Science and Technology，Wuhan 430079 Hubei， China）

Abstract：Osteoporosis （OP）is acommon metabolic bone and joint disease with a high incidence among midle-aged andelderlypeoplein China.Itis dificult tocureandsignificantlyreduces patients’qualityoflife.The kidney-tonifying and bone-strengthening prescription containing Drynariae Rhizoma is an efective formula foranti-OP.Naringin，the activeingredientofDrynariae Rhizoma，hasbeen proventoactonosteoclasts to inhibit bone resorption.Toexplore the mechanismof naringin on osteoclasts，this article reviews relevant research conductedover thepast two decades.It has ben found that naringin can regulate osteoclasts by modulating related signaling pathways，regulating immunecels， and mimicking estrogen-like effects.Our study may provide atheoretical basis for the clinical use of naringin in the treatment of OP and offer ideas for the development of original brand-named drugs for OP treatment.

Keywords：Drynariae Rhizoma；naringin；osteoclasts；osteoporosis；bone resorption；signaling pathways

骨质疏松症（osteoporosis，OP）是一种临床上常见的全身骨代谢疾病，以骨量下降或丢失、骨组织微结构损害、骨脆性增加、骨折风险性增大为主要特征。（剩余9588字）