短链脂肪酸对肠道动力的作用及其机制研究进展

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Research ProgressonRolesand MechanismsofShort-chainFattyAcids in IntestinalMotilityCHENQiJIANG Ya，JIANGuqinDeprtmentofGstronterologherstfiatedHositalfjingdicalUivesityng （210029）

Correspondence to： JIANG Liuqin， Email： jiangliuqin@163.com

AbstractShort-chain fattyacids （SCFAs）aremetabolitesof intestinal microbiota produced from dietary fiber fermentation.Theyregulate theintestinal motilitythrough multiplemechansmsincluding modulationof gastrointestinal hormones，enteric nervoussystem，smoothmusclecelsandinterstitialcellsofCajal（ICC）.AlerationsinSCFAsoceation have beenobserved in patients with intestinal motilitydisorders.Therapeutic interventions such as SCFAssupplementation， high-fiberdiets，probiotics/prebiotics，and fecal microbiota transplantation （FMT）havedemonstratedeficacyinimproving clinicalsymptoms.This articlereviewed research progressontheroles and mechanisms ofSCFAs in intestinalmotility.

KeyWordsShort-Chain FattyAcids;Gastrointestinal Motility；Intestinal Microbiota

肠道动力对营养物质的消化和吸收至关重要，但容易受多种因素的影响，包括免疫应答、肠神经系统、胆汁酸代谢、黏液分泌、肠道微生物群等。（剩余14820字）