白细胞介素-22在炎症性肠病中的研究进展

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Advances inResearch on Interleukin-22in Inflammatory Bowel DiseaseCAO Kejing'，CHEN Yingwei²2. 'DepartmentofGastroenterology，XinuaHospitalAfliatedtonghaiJiaoTongUniversityShoolofedicine，nghai ; ²Shanghai Key Laboratory ofPediatricGastroenterologyandNutrition，Shanghai

Correspondence to： CHEN Yingwei， Email： chenyingwei@xinhuamed.com.cn

AbstractInflammatorybowel disease（IBD）isachronicrelapsing inflammatorydisorderof thegastrointestinal tract. Interleukin（IL）-22，amemberoftheIL-1Ocytokiefamily，playsacriticalroleinprotectingtheitestinalepithelialbr andmaintaining gut homeostasis.Multiple studies indicate that IL-22can induce inflammationandpromote the inflammation-cancertransformationinBDunderdiferentconditions.Aditionaly，IL-22isintricatelyinvoledithe developmentand progressionofcolorectalcancer （CRC），positioning itasa promising therapeutic targetforanti-cancer interventions.Thisarticle reviewed the advancesin research onIL-22in IBD.

KeyWordsInterleukin-22；Inflammatory Bowel Disease;Colorectal Neoplasms

炎症性肠病（inflammatoryboweldisease，IBD）是由个体遗传易感性催化的对肠道微生物异常持续免疫反应引起的慢性复发性胃肠道炎性疾病，包括克罗恩病（Crohn'sdisease，CD）和溃疡性结肠炎（ulcerativecolitis，UC）。（剩余18516字）