坏死性凋亡在病毒感染性疾病中的研究进展

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Abstract：Necrotic apoptosis is a regulated mannerof celldeath，usuall triggered by the binding of death re ceptors and tumor necrosis factors or viral infection. Unlike cell apoptosis，necrotic apoptosis is characterized by cell sweling，membrane rupture，and the release of cytoplasmic contents，which may trigger an inflammatory response and surrounding tissue damage. The discovery process and molecular mechanism of necrotic apoptosis are reviewed，and the TNF- α signaling pathway and the formation of receptor interacting protein kinase 1（RIPK1）/receptor interacting protein kinase 3（RIPK3） complex are focused on discussing. At the same time，the central role of active oxygen in RIPK1-mediated necrotic apoptosis is emphasized and the key role of necrotic apoptosis in host antiviral defense is explained.This review providesa reference of the biological function of necrotic apoptosis and also a theoretical basis for the development of new therapeutic strategies.

Keywords： necrotic apoptosis；virus；programmed cell death；active oxygen

坏死性调亡的发现

坏死性凋亡是一种受调控的细胞死亡过程，其受细胞外及细胞内的信号调控，包括死亡受体-配体结合、病原体感染等，是不同于细胞凋亡、焦亡与自噬的细胞死亡方式。（剩余16378字）