肠道菌群及其代谢物在慢加急性肝衰竭发生发展中的作用

摘要：慢加急性肝衰竭（ACLF）病情凶险，发病迅速，短期病死率高。肠道菌群及其代谢物与ACLF发生发展和发病机制之间密切相关。ACLF进展过程中，肠道完整性破坏，肠道微生态及其代谢物失调，介导免疫紊乱，进而加重全身炎症性反应。本文旨在阐明肠道菌群及其代谢物在ACLF发展过程中的作用和相关治疗策略。

关键词：胃肠道微生物组；代谢；慢加急性肝功能衰竭

基金项目：国家中医药管理局高水平中医药重点学科建设项目（zyyzdxk-2023005）；首都卫生发展科研专项（首发2024-1-2173）；第七批全国老中医药专家学术经验继承工作；北京中医药科技发展资金项目（BJZYYB-2023-06）；北京市自然科学基金面上项目（7232272）

Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure

SHI Ke，ZHANG Qun，WANG Xianbo，FENG Ying

Center of Integrative Medicine，Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China

Corresponding author：WANG Xianbo，wangxianbo638@163.com （ORCID：0000-0002-3593-5741）

Abstract：Acute-on-chronic liver failure （ACLF） is a dangerous disease with severe conditions，rapid progression，and high short-term mortality. Intestinal flora and metabolites are closely associated with the development，progression，and pathogenesis of ACLF. During the development of ACLF，the destruction of intestinal integrity and the dysregulation of intestinal microecology and its metabolites mediate immune disturbance and thus aggravate systemic inflammatory response. This article elaborates on the role of intestinal flora and metabolites in the development and progression of ACLF and related therapeutic strategies.

Key words：Gastrointestinal Microbiome；Metabolism；Acute-On-Chronic Liver Failure

Research funding：Construction Project of High-level Key Disciplines of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine （zyyzdxk-202300）；Capital’s Funds for Health mprovement and Research （CFH2024-1-2173）；Seventh Batch of National Traditional Chinese Medicine Experts Academic Experience Inheritance Program；Beijing Traditional Chinese Medicine Technology Development Fund Project （BJZYYB-2023-06）；Beijing Municipal Natural Science Foundation （7232272）

慢加急性肝衰竭（acute-on-chronic liver failure，ACLF）是在慢性肝病基础上，多种急性打击导致的肝功能急性严重受损，短期内可出现多器官功能衰竭［1］。（剩余18208字）